angiotensin II receptor antagonist

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angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
Angiotensin II receptor antagonists have less adverse effects than ACE inhibitors, but may still cause xerostomia, taste alteration and orthostatic hypotension.
Concomitant use of ACE inhibitors and/or angiotensin II receptor antagonists may increase the risk of renal impairment, particularly in volume-depleted patients.
It should be used with caution in women on other medications that can increase potassium, including NSAIDs, potassium-sparing diuretics, ACE inhibitors, or angiotensin II receptor antagonists.
Candesartan prevents the narrowing of veins and arteries and is in the class of drugs called angiotensin II receptor antagonists.
Angiotensin II receptor antagonists generally are very well tolerated antihypertensive drugs, but they should be considered as a potential cause of acute reactions, even in patients who have taken them for years.
Comparative efficacy of two angiotensin II receptor antagonists, irbesartan and losartan, in mild-to-moderate hypertension.
By 2020, the drug classes typically used as first-, second- and third-line therapy--angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, calcium-channel blockers and diuretics--will all be subject to generic competition.
Estimated percentage of patients who are prescribed Diuretics, Beta Blockers (adrenergic receptor antagonists), Alpha Blockers (adrenergic receptor antagonists), Adrenergic Receptor Agonists, Calcium Channel Blockers, ACE Inhibitors, Angiotensin II Receptor Antagonists, Statins, Aldosterone Antagonists, Centrally Acting Antihypertensives, Vasodilators or other (specified).
Thiet stops antihypertensive medications in patients on ACE inhibitors or angiotensin II receptor antagonists for mild to moderate hypertension; these drugs can cause neonatal renal damage and are contraindicated during pregnancy.
Decision Resources also finds that the loss of patent protection of the angiotensin II receptor antagonists (AIIRAs) in the next few years will lead to a reduction in the size of the diabetic nephropathy market from 2012 to 2014.
By 2019, the drug classes typically used as first-, second-, and third-line therapy will all be subject to generic competition - these drug classes are the angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (AIIRA), calcium channel blockers (CCBs) and diuretics.
Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor antagonists.

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