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angiotensin II receptor antagonist |
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angiotensin II receptor antagonist Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others;
1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for
Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema. |
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angiostrophy angiotelectasis angiotensin angiotensin amide angiotensin I angiotensin II angiotensin II receptor antagonist Angiotensin II receptor antagonists angiotensin III angiotensin precursor angiotensin sensitivity test angiotensin-converting enzyme angiotensin-converting enzyme inhibitor Angiotensin-Converting Enzyme Inhibitors angiotensin-converting enzyme test |
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