angiostatin(redirected from Angiostatins)
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Related to Angiostatins: endostatin
Antiangiogenesis factor produced by some tumors, a 38-kD product of proteolytic plasminogen breakdown.
[angio- + G. statos, stalled, standing still, + -in]
A naturally occurring protein that is a specific inhibitor of endothelial proliferation and a potent angiogenesis inhibitor. It is under investigation as a potential cancer therapy.
angiostatin(an″jē-ō-stat′ĭn) [ angio- + statin]
A protein fragment of plasminogen that inhibits the growth of blood vessels, possibly by blocking the enzyme ATP synthase on the endothelium. It may shrink malignant tumors by decreasing their blood supply.