angiopoietin

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angiopoietin

(an″jē-ō-poy-ē′tĭn; -poy′ĕ-tĭn) [ angio- + -poiet(ic) + -in]
Any of several genes (or the proteins they encode) that stimulate new blood vessel formation. The proteins encoded by angiopoietin are found in healthy cardiac endothelium and in diseased tissues such as arthritic joints and malignant tumors.
References in periodicals archive ?
The angiopoietins are also involved in lymphangiogenesis, the formation of new lymphatic vessels, which plays a key role in tumor metastasis.
Moreover, antiangiogenic drugs used in the clinic are centered on the blockade of the VEGF-signaling pathway, whereas VEGF-independent angiogenic factors such as fibroblast growth factor, angiopoietins, placental growth factor (PlGF), matrix metalloproteases (MMPs), and ECM molecules are worth considering (6, 13).
2], either directly, or biosynthesised following induction of COX-1 and COX-2 in HeLa cells, elevates the expression of potent pro- angiogenic factors such as basic fibroblast growth factor 2, vascular endothelial growth factor (VEGF) and angiopoietins.
Different degrees of vascularization and their relationship to the expression of vascular endothelial growth factor, placental growth factor, angiopoietins and their receptors in first-trimester decidual tissues.
Angiopoietins consist of a family of four growth factors.
Cerebral malaria patients were found to have abnormal levels of proteins that regulate the activation of blood vessels known as angiopoietins.
It is now clear that angiogenesis is a very complex process and that other factors [including angiopoietins and platelet-derived growth factor (PDGF)] participate in the assembly and maturation of the vessel wall [3].
In PsA angiogenesis is prominent in both the synovium and psoriatic skin lesions, induced by angiogenic growth factors such as vascular endothelial growth factor (VEGF), transforming growth factor [beta] (TGF[beta]), and angiopoietins.
Expression of mRNA for VEGF, fibroblast growth factor-2 (FGF-2), soluble guanylate cyclase (sGC, NO receptor), and the angiopoietins (ANG) 1 and 2 by these luteal pericytes was evaluated using real time RT-PCR.
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development.