Anchorage dependence | definition of anchorage dependence by Medical dictionary
the need of normal cells for an appropriate surface to be attached to for them to grow in culture.The requirement by normal cells to attach to a surface to grow and divide in vitro; when cells lose anchorage dependence they no longer respond to external growth controls, which often correlates with tumourigenicity in vivo. It is a hallmark of malignant transformation and can be induced by oncogenic viruses
anchorage dependence A property of cells that can grow and proliferate only if fixed to a substrate. Many cancer cells do not show anchorage dependence and can be grown in a liquid culture.
References in periodicals archive
Indeed, the loss of anchorage dependence
is well documented in human and hamster nickel-transformed cells (Biedermann and Landolph 1987; Conway and Costa 1989; Costa et al.
Lipkin, Martin Rosenberg and their co-workers have shown CIF can restore contact inhibition, serum dependence and anchorage dependence
to malignant cells.