anaphylatoxin /ana·phyl·a·tox·in/ (-fil´ah-tok″sin) a substance produced in blood serum during complement fixation which serves as a mediator of inflammation by inducing mast cell degranulation and histamine release; on injection into animals, it causes anaphylactic shock.
anaphylatoxin
anaphylatoxin [an″ah-fil´ah-tok″sin]
an·a·phyl·a·tox·in or an·a·phyl·o·tox·in ( n  -f l-t k sn)n. A substance that may cause the release of histamine and other compounds that cause hypersensitivity, thus triggering some or all of the symptoms of anaphylaxis. |
anaphylatoxin
[an′əfī′lətok′sin]
a fragment (C3a, C4a, or C5a) that is produced during the pathways of the complement system. Along with other mechanisms, it mediates changes in mast cells leading to the release of histamine and other immunoreactive or inflammatory reactive substances. If the degranulation of mast cells is too strong, it can cause allergic reactions.
anaphylatoxin [an″ah-fil´ah-tok″sin]
a substance produced by complement activation that causes the release of histamine and other mediators of immediate hypersensitivity from basophils and mast cells, thereby producing signs and symptoms of immediate hypersensitivity (anaphylaxis) without involvement of IgE.
anaphylatoxin
a substance produced in blood serum when complement is activated; serves as a mediator of inflammation by inducing mast cell degranulation, histamine release and increased vascular permeability, and on injection into animals, it causes anaphylactic shock.
anaphylatoxin inhibitor
a specific serum carboxypeptidase, one of the complement proteins.
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