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beta-amyloid
(redirected from Amyloid beta)

   Also found in: Wikipedia 0.03 sec.
beta-amyloid
A4, β—amyloid Neurology A 4 kD polypeptide encoded on chromosome 21 arising from altered processing of amyloid precursor protein, an integral membrane glycoprotein secreted as a truncated carboxyl-terminal molecule; BA forms plaques in the brains of Pts with Alzheimer's disease–AD, Down syndrome, infectious encephalopathy, cerebral amyloid angiopathy; BA is found in skin, intestine, adrenal gland. See Alzheimer's disease, Amyloid, Presenilin. Cf Alpha2-macroglobulin.


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Chronically activated brain areas showed excess amyloid beta, the waxy protein tied to Alzheimer's (169: 3).
Mutations within the gene on chromosome 21, which encodes for amyloid precursor protein (APP), the precursor of amyloid beta (A[Beta]) peptides, are associated with 2% to 3% of all cases of the early-onset familial form of AD.
Zlokovic, who is known internationally for his work on stroke as well as Alzheimer's, focuses on the crucial role of blood vessels and has shown that blood circulation plays a key role in ridding the brain of the toxic amyloid beta that attacks the brains of Alzheimer's patients.
 
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