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beta-amyloid |
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beta-amyloid A4, β—amyloid Neurology A 4 kD polypeptide encoded on chromosome 21 arising from altered processing of amyloid precursor protein, an integral membrane glycoprotein secreted as a truncated carboxyl-terminal molecule; BA
forms plaques in the brains of Pts with Alzheimer's disease–AD, Down syndrome, infectious encephalopathy, cerebral amyloid angiopathy; BA is found in skin, intestine, adrenal gland. See Alzheimer's disease, Amyloid, Presenilin. Cf
Alpha2-macroglobulin. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Chronically activated brain areas showed excess amyloid beta, the waxy
protein tied to Alzheimer's (169: 3). Mutations within the gene on chromosome 21, which encodes for
amyloid precursor protein (APP), the precursor of amyloid beta (A[Beta])
peptides, are associated with 2% to 3% of all cases of the early-onset
familial form of AD. Zlokovic, who is known internationally for his work on stroke
as well as Alzheimer's, focuses on the crucial role of blood
vessels and has shown that blood circulation plays a key role in ridding
the brain of the toxic amyloid beta that attacks the brains of
Alzheimer's patients. |
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