In contrast to the studies on Amycolatopsis
and fungal degradation of PLA, the reports on the bacterial degradation of PLA and the purification of the correlative enzyme from bacteria are relatively less.
Vancomycin is a branched tricyclic glycosylated nonribosomal peptide produced by the fermentation of Amycolatopsis
orientalis, and it used in the treatment of infections caused by Gram-positive bacteria.
For example, a 5-dehydroxymethyl derivative of epoxyquinomicin C, isolated from Amycolatopsis
has shown a significant growth inhibition in hormone-refractory PCA cell line DU-145 through the induction of a apoptotic cell death (Kikuchi et al.
In the vancomycin producer Amycolatopsis
The posters are entitled "Genome Scanning Technology Reveals an Antibacterial Compound (ECO-0501) of a New Structural Class from the Vancomycin-Producer Amycolatopsis
orientalis," "ECO-0501, a Novel Anti-Gram Positive Compound Defining a New Antibacterial Structural Class: Preclinical Evaluations" and "ECO-0501, a Novel Anti-Gram Positive Compound Defining a New Antibacterial Structural Class: Mechanistic Studies.