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Amsterdam criteriaThe clinical criteria needed to diagnose hereditary nonpolyposis colorectal cancer (HNPCC—Lynch syndrome) in a family:
• There are at least three relatives with an HNPCC-associated cancer (large bowel, endometrium, small bowel, ureter or renal pelvis, but not stomach, ovary, brain, bladder or skin);
• One affected person is a first-degree relative of the other two;
• At least two successive generations are affected;
• At least one person was diagnosed before the age of 50 years;
• Familial adenomatous polyposis has been excluded;
• Tumours have been verified by pathologic examination.
Amsterdam criteriaOncology Criteria for diagnosing hereditary nonpolyposis colorectal cancer, see there.
- Family history
- Presence of histologically verified colorectal cancer in ≥ 3 relatives–one of whom is a 1st-degree relative of the other 2
- 'Vertical' history
- Presence of disease in ≥ 2 successive generations
- Age of onset
- Age < 50 in > 1 affected relative
- Hereditary polyposis syndromes have been excluded
A means of screening family members for evidence of a hereditary predisposition to colorectal cancer. People in families with nonpolyposis colorectal cancer are screened for evidence of other malignancies of the skin, endometrium, and stomach. Those who meet the Amsterdam criteria should be closely followed, e.g., with regular colonoscopies.