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Amsterdam criteria

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Amsterdam criteria
Oncology Criteria for diagnosing hereditary nonpolyposis colorectal cancer, see there
Amsterdam criteria
Family history
Presence of histologically verified colorectal cancer in ≥ 3 relatives–one of whom is a 1st-degree relative of the other 2
'Vertical' history
Presence of disease in ≥ 2 successive generations
Age of onset
Age < 50 in > 1 affected relative
Exclusion
Hereditary polyposis syndromes have been excluded


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All of the following are Amsterdam criteria for the diagnosis of the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome except:
CME Questions: colorectal cancer screening: today and tomorrow by Southern Medical Journal
The classic Amsterdam criteria (12) were the first developed to support the diagnosis of HNPCC.
Colorectal carcinoma in young females by Robilotti, James / Southern Medical Journal
20) The Amsterdam criteria are considered inadequate to address the whole picture of HNPCC in two aspects: (1) extracolonic tumors are not included and (2) cases with limited family history are inappropriately excluded.
Colorectal cancer in patients 20 years old or less in Taiwan by Wu, Tzee-Chung / Southern Medical Journal
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