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Amsterdam criteria

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Amsterdam criteria
Oncology Criteria for diagnosing hereditary nonpolyposis colorectal cancer, see there
Amsterdam criteria
Family history
Presence of histologically verified colorectal cancer in ≥ 3 relatives–one of whom is a 1st-degree relative of the other 2
'Vertical' history
Presence of disease in ≥ 2 successive generations
Age of onset
Age < 50 in > 1 affected relative
Exclusion
Hereditary polyposis syndromes have been excluded


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All of the following are Amsterdam criteria for the diagnosis of the Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome except: a.
The classic Amsterdam criteria (12) were the first developed to support the diagnosis of HNPCC.
20) The Amsterdam criteria are considered inadequate to address the whole picture of HNPCC in two aspects: (1) extracolonic tumors are not included and (2) cases with limited family history are inappropriately excluded.
 
 
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