amlodipine

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amlodipine

 [am-lo´dĭ-pēn]
a calcium channel blocking agent administered orally in the form of the besylate salt in treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

/am·lo·di·pine/ (am-lo´dĭ-pēn″) a calcium channel blocking agent used as the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

[amlō′dipēn]
a calcium channel blocker administered orally in the form of the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

A drug used in the treatment of ANGINA PECTORIS and high blood pressure (HYPERTENSION). A brand name is Istin.

amlodipine

calcium channel-blocking agent with similar actions to nifedipine (see Table 1)
Table 1: Drug treatment of hypertension
Drug typeExamplesComments
Thiazide diureticsBendroflumethiazide
Chlortalidone (Hygroton)
Cyclopenthiazide (Navidrex)
Indapamide (Natrilix)
Metolazone (Metenix 5)
Xipamide (Diurexan)
Indicated for hypertension in elderly patients
Tend to exacerbate diabetes, gout, systemic lupus erythematosus
May cause postural hypotension
Beta-blockers ('.…lol')Propranolol (Inderal)
Acebutolol (Sectral)
Atenolol (Tenormin)
Bisoprolol (Cardicor)
Carvedilol (Eucardic)
Celiprolol (Celectol)
Esmolol (Brevibloc)
Labetalol (Transdate)
Metoprolol (Betaloc)
Nadolol (Corgard)
Nebivol (Nebilet)
Oxprenolol (Trasicor)
Pindolol (Visken)
Sotalol (Beta-Cardone)
Timolol (Betim)
Should not be used by patients with asthma or bradycardia or hypotension
Should be avoided in patients with a history of Raynaud's
May cause distal paraesthesia, impotence, dizziness and exacerbation of psoriasis
Angiotensin-converting enzyme (ACE) inhibitors ('..…pril')Captopril
Cilazapril (Vascace)
Enalapril (Innovace)
Fosinopril (Staril)
Imidapril (Tanatril)
Lisinpril (Carace; Zestril)
Moexipril (Perdix)
Perindopril (Coversyl)
Quinapril (Accupro)
Ramipril (Tritace)
Trandolapril (Gopten)
Used only with care in patients taking diuretics, or those with peripheral vascular disease, generalized atherosclerosis and kidney disease
May cause profound hypotension, persistent cough, renal impairment, angioedema and pruritic rashes
Angiotensin II receptor antagonists ('.…sartan')Candesartan (Animax)
Eprosartan (Teveten)
Irbesartan (Aprovel)
Losartan (Cozaar)
Olmesartan (Olmetec)
Telmisartan (Micardis)
Valsartan (Diovan)
Used only with caution in patients with aortic or mitral valve stenosis, or renal artery disease
Tend not to be effective in Afro-Caribbean patients with left ventricular hypertrophy
Calcium-channel blockers ('.…dipine')Amlodipine (Istin)
Diltiazem (Calcicard)
Felodipine (Plendil)
Isradipine (Prescal)
Lacidipine (Motens)
Lercadidipine (Zanidip)
Nicardipine (Cardene)
Nifedipine (Adalat)
Nimodipine (Nimotrop)
Nisoldipine (Syscor MR)
Verapamil (Cordilox)
May cause abdominal pain, nausea, flushing, oedema, headache, dizziness, constipation and sleep disturbance
Alpha-blockers ('.…zosin')Doxazosin (Cardura)
Indoramin (Baratol)
Prazosin (Hypovase)
Terazosin (Hytrin)
Should not be used in patients with urinary incontinence
Tend to cause hypotension, dizziness, vertigo, headache, fatigue

Where antihypertensive drugs are used in combination, a rule-of-thumb guide indicates:

A + C (ACE inhibitors + calcium channel blockers)

B + D (beta-blockers + diuretics)

References in periodicals archive ?
This increase was driven by higher sales of sertraline and terbinafine partially offset by decrease in sales of amlodipine maleate.
The growth was primarily driven by higher price realizations for omeprazole and amlodipine maleate as well as launch of terbinafine.
Following the launch in March 2004, amlodipine maleate recorded full year revenues of Rs 220 million.
This growth was primarily driven by sales of omeprazole and amlodipine maleate.
Reddy's filed a New Drug Application (NDA) for amlodipine maleate under Section 505(b)(2) of the Federal Food, Drug and Cosmetic Act in December 2001.
Food and Drug Administration (FDA) had determined the NDA submitted by the Company for Amlodipine Maleate as "Approvable".
Reddy's filed a New Drug Application (NDA) for Amlodipine Maleate under Section 505 (b) (2) of the Federal Food, Drug and Cosmetic Act in December 2001.
Reddy Application On Amlodipine Maleate, Pfizer Says
re-evaluate the New Drug Application for amlodipine maleate submitted by Dr.
3 billion in FY05; YoY growth of 28% driven by higher pricing and volume growth in omeprazole and amlodipine maleate.