amlodipine


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Related to amlodipine: Bisoprolol

amlodipine

 [am-lo´dĭ-pēn]
a calcium channel blocking agent administered orally in the form of the besylate salt in treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

/am·lo·di·pine/ (am-lo´dĭ-pēn″) a calcium channel blocking agent used as the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

[amlō′dipēn]
a calcium channel blocker administered orally in the form of the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

A drug used in the treatment of ANGINA PECTORIS and high blood pressure (HYPERTENSION). A brand name is Istin.

amlodipine

calcium channel-blocking agent with similar actions to nifedipine (see Table 1)
Table 1: Drug treatment of hypertension
Drug typeExamplesComments
Thiazide diureticsBendroflumethiazide
Chlortalidone (Hygroton)
Cyclopenthiazide (Navidrex)
Indapamide (Natrilix)
Metolazone (Metenix 5)
Xipamide (Diurexan)
Indicated for hypertension in elderly patients
Tend to exacerbate diabetes, gout, systemic lupus erythematosus
May cause postural hypotension
Beta-blockers ('.…lol')Propranolol (Inderal)
Acebutolol (Sectral)
Atenolol (Tenormin)
Bisoprolol (Cardicor)
Carvedilol (Eucardic)
Celiprolol (Celectol)
Esmolol (Brevibloc)
Labetalol (Transdate)
Metoprolol (Betaloc)
Nadolol (Corgard)
Nebivol (Nebilet)
Oxprenolol (Trasicor)
Pindolol (Visken)
Sotalol (Beta-Cardone)
Timolol (Betim)
Should not be used by patients with asthma or bradycardia or hypotension
Should be avoided in patients with a history of Raynaud's
May cause distal paraesthesia, impotence, dizziness and exacerbation of psoriasis
Angiotensin-converting enzyme (ACE) inhibitors ('..…pril')Captopril
Cilazapril (Vascace)
Enalapril (Innovace)
Fosinopril (Staril)
Imidapril (Tanatril)
Lisinpril (Carace; Zestril)
Moexipril (Perdix)
Perindopril (Coversyl)
Quinapril (Accupro)
Ramipril (Tritace)
Trandolapril (Gopten)
Used only with care in patients taking diuretics, or those with peripheral vascular disease, generalized atherosclerosis and kidney disease
May cause profound hypotension, persistent cough, renal impairment, angioedema and pruritic rashes
Angiotensin II receptor antagonists ('.…sartan')Candesartan (Animax)
Eprosartan (Teveten)
Irbesartan (Aprovel)
Losartan (Cozaar)
Olmesartan (Olmetec)
Telmisartan (Micardis)
Valsartan (Diovan)
Used only with caution in patients with aortic or mitral valve stenosis, or renal artery disease
Tend not to be effective in Afro-Caribbean patients with left ventricular hypertrophy
Calcium-channel blockers ('.…dipine')Amlodipine (Istin)
Diltiazem (Calcicard)
Felodipine (Plendil)
Isradipine (Prescal)
Lacidipine (Motens)
Lercadidipine (Zanidip)
Nicardipine (Cardene)
Nifedipine (Adalat)
Nimodipine (Nimotrop)
Nisoldipine (Syscor MR)
Verapamil (Cordilox)
May cause abdominal pain, nausea, flushing, oedema, headache, dizziness, constipation and sleep disturbance
Alpha-blockers ('.…zosin')Doxazosin (Cardura)
Indoramin (Baratol)
Prazosin (Hypovase)
Terazosin (Hytrin)
Should not be used in patients with urinary incontinence
Tend to cause hypotension, dizziness, vertigo, headache, fatigue

Where antihypertensive drugs are used in combination, a rule-of-thumb guide indicates:

A + C (ACE inhibitors + calcium channel blockers)

B + D (beta-blockers + diuretics)

References in periodicals archive ?
compared to the combination of perindopril plus amlodipine on central arterial blood pressure in patients with moderate-to-severe hypertension: Rationale and design of the SEVITENSION study.
The calcium channel blocker amlodipine lowers blood pressure by relaxing the blood vessel walls through the inhibition of calcium.
Amlodac introduces a cost-effective treatment option for new hypertensives and the perfect generic switch for patients established on the original amlodipine besylate.
The results showed a coherence of data in favor of amlodipine, and are also consistent with those from other studies, he said.
It wasn't surprising that chlorthalidone was better than amlodipine for preventing new cases of heart failure, he added.
Reddy's Amlodipine Besylate and Benazepril Hydrochloride capsules 5 mg/40 mg and 10 mg/40 mg strengthsareavailable in 100 count bottles.
Amlodipine and valsartan tablets contain amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg providing for the following available combinations: 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg, and 10 mg/320 mg strengths.
New clinical trial data, from the phase 4 Sevitension Study, will be presented at the 23rd European Meeting on Hypertension and Cardiovascular Protection (ESH) in Milan, comparing FDC treatment olmesartan and amlodipine with perindopril and amlodipine in reducing central aortic blood pressure.
9% on the amlodipine arm and fasting plasma glucose levels were 8.
Administered in combination, atorvastatin and amlodipine have been shown in a study to be significantly more effective in achieving recommended levels of systolic BP and LDL-C.
The second drug accepted for review, Exforge (amlodipine besylate/valsartan), utilizes two complementary mechanisms of action through the calcium channel blocker (CCB) amlodipine and the angeiotensin receptor blocker (ARB) valsartan.
In the 42,418-patient trial, researchers compared four types of antihypertensive drugs: the [alpha]-blocker doxazosin, the diuretic chlorthalidone, the ACE-inhibitor lisinopril, and the calcium channel blocker amlodipine.