aminoglutethimide

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aminoglutethimide

 [ah-me″no-gloo-teth´ĭ-mīd]
an antihormone that inhibits conversion of cholesterol to pregnenolone, thus reducing adrenocortical steroid synthesis; administered orally in treatment of cushing's syndrome. It also inhibits conversion of androstenedione to estrone in peripheral tissues and is sometimes used as a componnt of hormonal therapy for advanced breast carcinoma.

aminoglutethimide

/ami·no·glu·teth·i·mide/ (-gloo-teth´ĕ-mīd) an inhibitor of cholesterol metabolism, thereby reducing adrenocortical steroid synthesis; used in the treatment of Cushing's syndrome. It also inhibits estrogen production from androgens in peripheral tissue.

aminoglutethimide

Oncology A nonsteroidal aromatase inhibitor which inhibits estrogen production and suppresses estrogen-dependent tumor growth. See Estrogen-receptor.

aminoglutethimide (əmē´nōglōōteth´əmīd),

n brand name: Cytadren;
drug class: antineoplastic, adrenal steroid inhibitor;
action: acts by inhibiting the enzymatic conversion of cholesterol to pregnenolone, thereby blocking synthesis of all adrenal steroids;
uses: suppression of adrenal function in Cushing's syndrome, metastatic breast cancer, and adrenal cancer.

aminoglutethimide

a compound that inhibits the adrenal cortex and peripheral aromatase, thereby blocking production of adrenal steroids. Used in the treatment of hyperadrenocorticism.