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Psychiatry Adolescent Depression Antidepressant and Psychotherapy. A clinical trial that compared healthcare outcomes of treatment with selective serotonin reuptake inhibitors (SSRIs) plus cognitive behaviour therapy (CBT) versus SSRI alone in adolescents with major depression.
Conclusion The SSRI + CBT group was more expensive than the SSRI-only group and no more cost-effective. There was an average decrease in suicidal thoughts and self-harm and no significant increase in disinhibition, irritability and violence compared to baseline
Rheumatology Arthritis, Diet and Activity Promotion Trial. A clinical trial that queried the effect of lifestyle modification on physical function, pain, and disability in obese, sedentary older adults with knee OA