ADAPT

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Neurology Alzheimer's Disease Anti-Inflammatory Prevention Trial. A prevention trial which investigated whether inflammation is linked to the neurodegenerative changes of Alzheimer's disease and, if so, whether NSAIDs—e.g., naproxen and celecoxib—provide any benefit
Psychiatry Adolescent Depression Antidepressant and Psychotherapy. A clinical trial that compared healthcare outcomes of treatment with selective serotonin reuptake inhibitors (SSRIs) plus cognitive behaviour therapy (CBT) versus SSRI alone in adolescents with major depression.
Conclusion The SSRI + CBT group was more expensive than the SSRI-only group and no more cost-effective. There was an average decrease in suicidal thoughts and self-harm and no significant increase in disinhibition, irritability and violence compared to baseline
Rheumatology Arthritis, Diet and Activity Promotion Trial. A clinical trial that queried the effect of lifestyle modification on physical function, pain, and disability in obese, sedentary older adults with knee OA
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