amantadine /aman·ta·dine/ (ah-man´tah-dēn) an antiviral compound used as the hydrochloride salt to treat influenza A; also used as an antidyskinetic in the treatment of parkinsonism and drug-induced extrapyramidal reactions.
amantadine (
man´tidēn),
Amantadine™
amantadine (
man´tidēn),n an antiviral that prevents uncoating and replication of the influenza A virus; most effectively used in the early stages of exposure.
Amantadine™
Therapeutics An antiviral that prevents the release of viral nucleic acid into the host cells, which is most effective against influenza virus; in parkinsonism, amantadine ↑ presynaptic dopamine release, blocks dopamine
reuptake into the presynaptic neurons, and has anticholinergic effects Adverse effects Nausea, vertigo, confusion, hallucinations, anxiety, restlessness, depression, irritability, peripheral edema, orthostatic hypotension, psychotic reaction
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