Amanita phalloides


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Related to Amanita phalloides: Amanita muscaria, Amanita ocreata

Am·a·ni·ta phal·loi·'des

a species of fungus containing poisonous elements, including phalloidin and amanitin, which cause gastroenteritis, hepatic necrosis, and renal necrosis.
Synonym(s): deadly agaric
A mushroom which, along with related species—A bisporigera, A verna, A virosa—is the most common cause of fatal mushroom poisonings
Mechanism The major toxins are amanatins, a series of closely related heat-stable cyclic octapeptides, which inhibit RNA polymerase in liver cells
Management Symptomatic-rehydration, IV glucose, instillation of 100 g of activated charcoal per os, mannitol to prevent oliguria; 50% of late-treated patients die

Amanita phalloides

Toxicology A mushroom which, with related species–A bisporigera, A verna, A virosa are the most common cause of fatal mushroom poisonings Clinical After a 12-hr latency, N&V, abdominal colic, severe watery diarrhea; this is followed by a 24-hr latency period, then–if the amount ingested was significant—by fatal hepatitis and renal failure Management Symptomatic-rehydration, IV glucose, instillation of 100 g of activated charcoal per os, mannitol to prevent oliguria; 50% of late-treated Pts die. See Poisonous mushroom.

Am·a·ni·ta phal·loi·des

(am'ă-nī'tă fă-loy'dēz)
A species of mushroom containing poisonous principles (including phalloidin and amanitin) that cause gastroenteritis, hepatic necrosis, and renal necrosis.
References in periodicals archive ?
In December 2016, fourteen cases of Amanita phalloides poisoning were identified by the California Poison Control System (CPCS) among persons who had consumed foraged wild mushrooms.
Uno de los problemas por los que se retrasa el tratamiento del paciente que ingiere Amanita phalloides es la presentacion tardia de los sintomas de intoxicacion, la cual puede darse entre 6-12 horas posteriores a la ingesta.
Amanita phalloides poisoning: reassessment of prognotic factors and indications for emergency liver transplantation.
Hemoperfusion Is Life Saving in Amanita phalloides Intoxication.
Furthermore, patients treated with high doses of silymarin (or its most active component, silybin) shortly after ingesting the deadly toadstool, Amanita phalloides, survive; and multiple studies of silymarin in experimental animal models show it has a broad spectrum of hepatoprotective and antioxidant effects, protecting them against injury from several toxins, including Amanita phalloides, carbon tetrachloride, ethanol, and galactosamine, even when given after exposure (Vogel et al.
Phallolysin from Amanita phalloides is cytotoxic to HeLa cells and ascites tumor cells (sarcoma P43 of the mouse), Pleurotus ostreatus hemolysin possesses antiproliferation activities against human fibrosarcoma cancer cells HT-1080 and against human breast adenocarcinoma cancer MCF-7 cell lines, and Pleurotus eryngii hemolysin reduces the viability of leukemia L1210 cells (Berne et al.
The second question involved a suspected Amanita phalloides poisoning.
From December 28, 1996, through January 6, 1997, nine persons in northern California required hospitalization after eating Amanita phalloides (i.
Amanita phalloides - commonly known as the death cap mushroom - poisoned five San Francisco Bay Area people earlier this year, forcing one 13-year-old girl to undergo a nine-hour partial liver transplant.
Based on the available clinical evidence it can be concluded - concerning possible risks /probable benefits - that it is reasonable to employ silymarin as a supportive element in the therapy of Amanita phalloides poisoning but also (alcoholic and grade Child 'A') liver cirrhosis.
The diagnosis of suspected poisoning by Amanita phalloides remains a challenge to emergency physicians.