altitude sickness

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Altitude Sickness



Altitude sickness is a general term encompassing a spectrum of disorders that occur at higher altitudes. Since the severity of symptoms varies with altitude, it is important to understand the range of the different altitudes that may be involved. High altitude is defined as height greater than 8,000 feet (2,438m); medium altitude is defined as height between 5,000 and 8,000 feet (1,524-2,438m); and extreme altitude is defined as height greater than 19,000 feet (5,791 m). The majority of healthy individuals suffer from altitude sickness when they reach very high altitudes. In addition, about 20% of people ascending above 9,000 feet (2,743m) in one day will develop altitude sickness. Children under six years and women in the premenstrual part of their cycles may be more vulnerable. Individuals with preexisting medical conditions—even a minor respiratory infection—may become sick at more moderate altitudes.


There are three major clinical syndromes that fall under the heading of altitude sickness: acute mountain sickness (AMS), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE). These syndromes are not separate, individual syndromes as much as they are a continuum of severity, all resulting from a decrease in oxygen in the air. AMS is the mildest, and the other two represent severe, life-threatening forms of altitude sickness.
Altitude sickness occurs because the partial pressure of oxygen decreases with altitude. (Partial pressure is a term applied to gases that is similar to the way the term concentration is applied to liquid solutions.) For instance, at 18,000 feet (5,486 m) the partial pressure of oxygen drops to one-half its value at sea level and, therefore, there is a substantially lower amount of oxygen available for the individual to inhale. This is known as hypoxia. Furthermore, since there is less oxygen to inhale, less oxygen reaches the blood. This is known as hypoxemia. These two conditions are the major factors that form the basis for all the medical problems associated with altitude sickness.
As a person becomes hypoxemic, his natural response is to breathe more rapidly (hyperventilate). This is the body's attempt to bring in more oxygen at a rapid rate. This attempt at alleviating the effects of the hypoxia at higher altitudes is known as acclimatization, and it occurs during the first few days. Acclimatization is a response that occurs in individuals who travel from lower to higher altitudes. There are groups of people who have lived at high altitudes (for example, in the Himalayan and Andes mountains) for generations, and they are simply accustomed to living at such altitudes, perhaps through a genetic ability.

Causes and symptoms

Acute mountain sickness (AMS) is a mild form of altitude sickness that results from ascent to altitudes higher greater than 8,000 feet (2,438m)—even 6,500 feet (1,981 m) in some susceptible individuals. Although hypoxia is associated with the development of AMS, the exact mechanism by which this condition develops has yet to be confirmed. It is important to realize that some individuals acclimatize to higher altitudes more efficiently than others. As a result, under similar conditions some will suffer from AMS while others will not. At present, the susceptibility of otherwise healthy individuals to contracting AMS cannot be accurately predicted. Of those who do suffer from AMS, the condition tends to be most severe on the second or third day after reaching the high altitude, and it usually abates after three to five days if they remain at the same altitude. However, it can recur if the individuals travel to an even higher altitude. Symptoms usually appear a few hours to a few days following ascent, and they include dizziness, headache, shortness of breath, nausea, vomiting, loss of appetite, and insomnia.

Key terms

Cerebral — Pertaining to the brain.
Edema — Accumulation of excess fluid in the tissues of the body.
Hypoxemia — Insufficient oxygenation of the blood.
Hypoxia — A deficiency in the amount of oxygen required for effective ventilation.
Pulmonary — Pertaining to the lungs.
High-altitude pulmonary edema (HAPE) is a life-threatening condition that afflicts a small percentage of those who suffer from AMS. In this condition, fluid leaks from within the pulmonary blood vessels into the lung tissue. As this fluid begins to accumulate within the lung tissue (pulmonary edema), the individual begins to become more and more short of breath. HAPE is known to afflict all types of individuals, regardless of their level of physical fitness.
Typically, the individual who suffers from HAPE ascends quickly to a high altitude and almost immediately develops shortness of breath, a rapid heart rate, a cough productive of a large amount of sometimes bloody sputum, and a rapid rate of breathing. If no medical assistance is provided by this point, the patient goes into a coma and dies within a few hours.
High-altitude cerebral edema (HACE), the rarest and most severe form of altitude sickness, involves cerebral edema, and its mechanism of development is also poorly understood. The symptoms often begin with those of AMS, but neurologic symptoms such as an altered level of consciousness, speech abnormalities, severe headache, loss of coordination, hallucinations, and even seizures. If no intervention is implemented, death is the result.


The diagnosis for altitude sickness may be made from the observation of the individual's symptoms during travel to higher altitudes.


Mild AMS requires no treatment other than an aspirin or ibuprofen for headache, and avoidance of further ascent. Narcotics should be avoided because they may blunt the respiratory response, making it even more difficult for the person to breathe deeply and rapidly enough to compensate for the lower levels of oxygen in the environment. Oxygen may also be used to alleviate symptoms of mild AMS.
As for HAPE and HACE, the most important course of action is descent to a lower altitude as soon as possible. Even a 1,000-2,000-foot (305-610 m) descent can dramatically improve one's symptoms. If descent is not possible, oxygen therapy should be started. In addition, dexamethasone (a steroid) has been suggested in order to reduce cerebral edema.


The prognosis for mild AMS is good, if appropriate measures are taken. As for HAPE and HACE, the prognosis depends upon the rapidity and distance of descent and the availability of medical intervention. Descent often leads to improvement of symptoms, however, recovery times vary among individuals.


When individuals ascend from sea level, it is recommended that they spend at least one night at an intermediate altitude prior to ascending to higher elevations. In general, climbers should take at least two days to go from sea level to 8,000 feet (2,438m). After reaching that point, healthy climbers should generally allow one day for each additional 2,000 feet (610m), and one day of rest should be taken every two or three days. Should mild symptoms begin to surface, further ascent should be avoided. If the symptoms are severe, the individual should return to a lower altitude. Some reports indicate that acetazolamide (a diuretic) may be taken before ascent as a preventative measure for AMS.
Paying attention to diet can also help prevent altitude sickness. Water loss is a problem at higher altitudes, so climbers should drink ample water (enough to produce copious amounts of relatively light-colored or clear urine). Alcohol and large amounts of salt should be avoided. Eating frequent small, high-carbohydrate snacks (for example, fruits, jams and starchy foods) can help, especially in the first few days of climbing.



Crystal, R. G., et al., editors. The Lung: Scientific Foundations. Lippincott-Raven Publishers, 1997.

altitude sickness

a syndrome caused by exposure to altitude high enough to cause significant hypoxia (lack of oxygen). At high altitudes the atmospheric pressure, and thus arterial oxygen content, are decreased. Called also high-altitude sickness and mountain sickness.

Acute altitude sickness may occur after a few hours' exposure to a high altitude. Mental functions may be affected; there may be lightheadedness and breathlessness; and eventually headache and prostration may occur. Older persons and those with pulmonary or cardiovascular disease are most susceptible. After a few hours or days of acclimation the symptoms will subside.

Chronic altitude sickness (called also Monge's disease and Andes disease) occurs in those living in the high Andes above 15,000 feet. It resembles polycythemia, but is completely relieved if the patient is moved to sea level.

al·ti·tude sick·ness

a syndrome caused by low inspired oxygen pressure (as at high altitude) and characterized by nausea, headache, dyspnea, malaise, and insomnia; in severe instances, pulmonary edema and adult respiratory distress syndrome can occur; Synonym(s): Acosta disease, mountain sickness, puna, soroche

altitude sickness

A collection of symptoms, including shortness of breath, headache, and nosebleed, brought on by decreased oxygen in the atmosphere, such as that encountered at high altitudes.

altitude sickness

a syndrome associated with the relatively lower amount of oxygen in the atmosphere at altitudes encountered during mountain climbing or travel in unpressurized aircraft. Symptoms of mild altitude illness include headache, difficulty sleeping, loss of appetite, nausea and vomiting, fatigue, dizziness, rapid heart rate, and shortness of breath, especially on exertion. In severe cases, high-altitude pulmonary or cerebral edema may result, requiring emergency treatment and removal to lower altitudes. Also called acute mountain sickness, the bends, Monge's disease.
A syndrome affecting those living for various periods at high altitudes, which is diagnosed if a person has 3+ major symptoms: anorexia, dyspnoea, fatigue, headache, insomnia, which generally responds to dexamethasone. Mountain sickness is divided into acute and chronic forms

altitude sickness

Mountain sickness, see there.

al·ti·tude sick·ness

(al'ti-tūd sik'nĕs)
A syndrome caused by low inspired oxygen pressure (as at high altitude) and characterized by nausea, headache, dyspnea, malaise, and insomnia; in severe instances, pulmonary edema and adult respiratory distress syndrome can occur.
Synonym(s): Acosta disease, aerial sickness, mountain sickness.

altitude sickness

A disorder occurring in unadapted people who proceed rapidly to altitudes above about 4,000 m. There is a sense of fullness in the chest, headache, nausea, loss of appetite and sleeplessness, and the condition may progress, sometimes suddenly, to a malignant and highly dangerous phase. This is a dangerous condition characterized by excess fluid (oedema) in the lungs and the brain. Also known as mountain sickness.


Joseph (José) de, Spanish Jesuit missionary, 1539-1600.
Acosta disease - Synonym(s): altitude sickness

altitude sickness, altitude disease

a disease of animals in North and South America and north Africa at altitudes above 1,500-2,000 meters. Caused by the particular sensitivity and constrictive response of ruminant pulmonary arteriolar musculature to anoxia. The result is pulmonary hypertension and the risk of cor pulmonale. There is an age and resident risk. Those with even a minor impairment of the circulatory or respiratory systems may not be able to find sufficient cardiac reserve to compensate for the extra dynamic load created by the altitudinal anoxia, so that congestive heart failure develops. The risk for heart failure is increased by the ingestion of the indolizidine alkaloid swainsonine present in pasture Astragalus and Oxytropis. Called also brisket disease, mountain sickness, high mountain disease.
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