alternative splicing

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alternative splicing

different ways of assembling exons to produce different mature mRNAs.

al·ter·na·tive splic·ing

(awl-tĕr'nă-tiv splīs'ing)
Different ways of assembling exons to produce different mature mRNAs.

alternative splicing

process in which RNA PRIMARY TRANSCRIPTS (containing INTRONS as well as EXONS) of some genes give rise to related, but different, mature mRNAs, by differences in RNA SPLICING so that different combinations of exons assemble. This increases the coding capacity of the GENOME and results in the synthesis of a range of related PROTEINS, called isoforms. Alternative splicing is also called DIFFERENTIAL SPLICING.
References in periodicals archive ?
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts.
Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development.
To order Jivan's PCR primers for alternate splicing, visit http://www.
CEO and Founder of Jivan Biologics, "Jivan now offers catalogue arrays for alternate splicing for every stage of the drug development pipeline from target discovery, target validation and functional genomics to predictive toxicology, personalized medicine and the search for clinical markers in blood.
Jivan began developing its first gene family array for alternate splicing in kinases in 2002 as part of a research collaboration with Sugen, Inc.
TransExpress(TM) microarrays for alternate splicing can be ordered online at http://www.
May 31 /PRNewswire/ -- The first commercial genome-wide microarrays for alternate splicing were launched today by Jivan Biologics, Inc.

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