alternative complement pathway

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pathway

 [path´wa]
a course usually followed. In neurology, the nerve structures through which a sensory impression is conducted to the cerebral cortex (afferent pathway), or through which an impulse passes from the brain to the skeletal musculature (efferent pathway). Also used alone to indicate a sequence of reactions that convert one biological material to another (metabolic pathway).
accessory pathway (accessory conduction pathway) extra muscle tissue between the atrium and ventricle that bypasses all or part of the normal conduction system. When the ventricles are activated prematurely via this pathway, initial forces are slow, producing the delta wave of wolff-parkinson-white syndrome, and preexcitation is said to exist; the delta wave causes the PR interval to shorten and the QRS interval to broaden.
alternative complement pathway see complement.
amphibolic pathway a group of metabolic reactions with a dual function, providing small metabolites for further catabolism to end products or for use as precursors in synthetic, anabolic reactions. The tricarboxylic acid cycle is an example. See also anabolism and catabolism.
biosynthetic pathway the sequence of enzymatic steps in the synthesis of a specific end-product in a living organism.
classical complement pathway see complement.
common pathway of coagulation the steps in the mechanism of coagulation (see clotting) from the activation of factor x through the conversion of fibrinogen to fibrin. See also intrinsic pathway of coagulation and extrinsic pathway of coagulation.
concealed accessory pathway an accessory pathway that has only retrograde conduction; thus its PR and QRS complexes are normal on the electrocardiogram, but there is a tendency to develop premature supraventricular tachycardia. If atrial fibrillation develops, conduction will proceed across the atrioventricular node.
Embden-Meyerhof pathway the series of enzymatic reactions in the anaerobic conversion of glucose to lactic acid, resulting in energy in the form of adenosine triphosphate (ATP).
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor vii and leading to activation of factor x, which induces the reactions of the common pathway of coagulation. See also intrinsic pathway of coagulation.
final common pathway
1. the motor neurons by which nerve impulses from many central sources pass to a muscle or gland in the periphery.
2. any mechanism by which several independent effects exert a common influence.
intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor xii. This is followed by the sequential activation of factors xi and ix, which results in the activation of factor x. Activated factor X (factor Xa) initiates the common pathway of coagulation. See also extrinsic pathway of coagulation.
pentose phosphate pathway a pathway of hexose oxidation in which glucose-6-phosphate undergoes two successive oxidations by NADP, the final forming a pentose phosphate.

alternative complement pathway

Properdin pathway Immunology A route of complement activation that occurs independently of complement-fixing antibodies; the ACP is more complex than the classic complement pathway; it requires a 'priming' C3 convertase–C3,Bb, and an 'amplification' C3 convertase–C3b,Bb; in the presence of properdin, C3 convertase is stabilized, activating later complement components, which leads to opsonization, leukocyte chemotaxis, ↑ vascular permeability, and cytolysis; ACP is activated by properdin, IgA, IgG, lipopolysaccharide, and snake venom; both pathways are stimulated by trypsin-like enzymes. Cf Complement.
References in periodicals archive ?
Cisplatin goes through the p16 and p53 pathways, while the curcumin uses an alternate pathway," said Dr.
The microsomal ethanol oxidizing system (MEOS), which is generated by hepatocytes and hepatic enzymes including CYP2E1, CYP1A2, and CYP3A, is an alternate pathway for ethanol metabolism (Lieber 1999; Garcia-Banuelos et al.
If a team member or partner suggests an alternate pathway to the summit, or if we run into a brick wall in the path we're on, can we be creative and flexible enough to find another way, while progressing ever upwards?
The enzyme acts by converting asparagine present in potatoes and cereal products to aspartic acid, which is channeled through an alternate pathway in the Maillard reaction.
Activation of the receptor by the agonist (ATP or UTP) leads to an increase in the concentration of intracellular calcium, thereby mediating the opening of calcium-dependent chloride channels and serving as an alternate pathway for chloride secretion.
The alternate pathway is to satisfactorily practice neurotology for at least a 7-year period.
Pharmacists who do not wish to fill a prescription for Previn or for other abortion-inducing drugs must refer the woman to an alternate pathway for securing their abortion drug of choice--or face disciplinary action, potentially depriving them of their right to practice their profession.
Furthermore, through what's called the alternate pathway, the complement cascade can sometimes proceed even without alpha-gal antibodies.
Project: Creating an independent study program as an alternate pathway to accessing learning opportunities, enabling more students to stay in school.
2+], whereas activation of the alternate pathway requires only [Mg.
Not only does Subpart H offer an alternate pathway for potential approval of Riquent, but it also may enable an accelerated approval of Riquent, allowing patients to gain access to Riquent while an additional post-marketing study is ongoing.
Vertex plans to characterize further the activity of VX-710 in this alternate pathway of multidrug resistance.

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