Alphavirus


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Related to Alphavirus: bunyavirus, flavivirus, Hepacivirus, Rubivirus

Al·pha·vi·rus

(al'fă-vī'rŭs),
One of the genera of the family Togaviridae that was formerly classified as part of the "group A" arboviruses and includes the viruses that cause eastern equine, western equine, and Venezuelan encephalitis.

Alphavirus

/Al·pha·vi·rus/ (al´fah-vi″rus) a genus of viruses of the family Togaviridae that cause encephalitis or febrile illness with rash or arthralgia.

alphavirus

(ăl′fə-vī′rəs)
n.
Any of a genus of single-stranded RNA viruses that infect animals and cause diseases such as chikungunya and Eastern equine encephalitis.

alphavirus

[al′favī′rəs]
any of a group of very small Toga viruses consisting of a single molecule of single-stranded ribonucleic acid within a lipoprotein capsule. Many alphaviruses multiply in the cytoplasm of cells of arthropods and are transmitted to humans from mosquitoes, such as those causing equine encephalitis and Semiliki Forest virus. See also encephalitis, Toga virus.

alphavirus

A member of the group-IV Togaviridae, characterised by 70-nm virions surrounding a 40-nm isometric nucleocapsid, which contains a single-stranded linear RNA.

Pathogenic alphaviruses
Eastern, Western and Venezuela equine encephalitis viruses; Sindbis virus; Semliki Forest virus (which may be used as a vector for heterologous gene expression); Ross River; O’Nyong-Nyong virus.
 
Epidemiology
Pathogenic alphaviruses of the Western hemisphere occur primarily in the summer.
 
Clinical findings
Headache, fever, chills, nausea, vomiting, mental confusion, somnolence.
 
Lab
Lymphocytosis and increased protein in CSF.
 
Management
Supportive, intensive nursing care.
 
Sequelae
Neurologic effects (e.g., mental retardation), convulsions, paralysis in 30–70% of survivors.

alphavirus

Group A arbovirus Virology A genus of the family Togaviridae characterized by 50-60 nm virions containing a single-stranded linear RNA Pathogenic alphaviruses Eastern, western, and Venezuela equine encephalitis viruses, Sindbis virus and Semliki Forest viruses–which may be used as vectors for expressing heterologous genes, Ross River, o'nyong-nyong virus Epidemiology Pathogenic alphaviruses of the Western hemisphere occur primarily in the summer Clinical Headache, fever, chills, N&V, mental confusion, somnolence Laboratory Lymphocytosis and ↑ protein in CSF Management Supportive, intensive nursing care Sequelae Neurologic effects–eg, mental retardation, convulsions, paralysis in 30–70% of survivors

Al·pha·vi·rus

(al'fă-vī'rŭs)
One of the genera of the family Togaviridae that was formerly classified as part of the "group A" arboviruses and includes the viruses that cause eastern equine, western equine, and Venezuelan encephalitis.

Alphavirus

one of the two genera in the family Togaviridae; includes eastern, western and Venezuelan equine encephalomyelitis viruses and Getah virus. All of them replicate in arthropod vectors including mosquitoes.
References in periodicals archive ?
The molecular and cellular aspects of arthritis due to alphavirus infections: lesson learned from Ross River virus.
He won't stop making vaccines against single strains of alphavirus while waiting for this to happen, he adds.
Filling the current gaps in sequence data for geographic and temporal distributions of MAYV is needed to increase the phylogenetic resolution and aid our understanding of the evolution and spread of this emerging arthralgic alphavirus in the Americas.
Smith also directed epidemic investigation and assistance teams that helped control alphavirus outbreaks in South America and identify West Nile virus as the cause of the outbreak in New York in 1999.
Contract Awarded for the clinical assessment of a Multivalent Alphavirus DNA vaccine delivered by Electroporation
Our novel, proprietary i-[eth]VLP technology was created utilizing alphavirus VLPs.
The PSMA-VRP vaccine is based on the platform alphavirus replicon vector technology system (a non-replicating viral vector system), and was developed under license from AlphaVax, Inc.
Chikungunya virus (CHIKV), a mosquitoborne alphavirus, family Togaviridae, causes an acute illness, manifested as fever and severe arthralgia (I).
In an early research study, viral isolates from adenovirus, alphavirus, enterovirus, flavivirus, herpes virus and human parvovirus B19 were injected into human plasma specimens from healthy volunteers.
is a North Carolina-based, clinical-stage company that uses a proprietary alphavirus vector platform technology that has proven to be highly flexible and immunogenic, and allows the same manufacturing, formulation, and delivery strategies to be applied to many different products.
Chikungunya virus (CHIKV) is an arbovirus that belongs to the genus Alphavirus (family Togaviridae).
Getah virus (genus Alphavirus, family Togaviridae) is a mosquito-borne virus that was first isolated in Malaysia in 1955 from Culex spp.