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alphavirus |
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Alphavirus /Al·pha·vi·rus/ (al´fah-vi″rus) a genus of viruses of the family Togaviridae that cause encephalitis or febrile illness with rash or arthralgia.
alphavirus [al′favī′rəs] any of a group of very small togaviruses consisting of a single molecule of single-stranded ribonucleic acid within a lipoprotein capsule. Many alphaviruses multiply in the cytoplasm of cells of arthropods and are transmitted to humans from mosquitoes, such as those causing equine encephalitis and Semiliki Forest virus. See also encephalitis, togavirus. Alphavirus one of the two genera in the family Togaviridae; includes eastern, western and Venezuelan equine encephalomyelitis viruses and Getah virus. All of them replicate in arthropod vectors including mosquitoes. alphavirus Group A arbovirus Virology A genus of the family Togaviridae characterized by 50-60 nm virions containing a single-stranded linear RNA Pathogenic alphaviruses Eastern, western, and Venezuela equine encephalitis viruses, Sindbis
virus and Semliki Forest viruses–which may be used as vectors for expressing heterologous genes, Ross River, o'nyong-nyong virus Epidemiology Pathogenic alphaviruses of the Western hemisphere occur primarily in the summer Clinical
Headache, fever, chills, N&V, mental confusion, somnolence Laboratory Lymphocytosis and ↑ protein in CSF Management Supportive, intensive nursing care Sequelae Neurologic effects–eg, mental retardation, convulsions, paralysis in
30–70% of survivors How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| ? Mentioned in | ? References in periodicals archive | |
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He is focusing on three different
species of alphavirus to determine which genes to include in the
polyvalent vaccine. Chikungunya, a mosquitoborne disease first described in Tanzania
(formerly Tanganyika) in eastern Africa in 1952, is caused by
chikungunya virus (CHIKV), an alphavirus belonging to the Togaviridae
family.
Sindbis virus is a model virus for the Alphavirus group, which contains
the highly pathogenic and weaponizable Eastern, Western and Venezuelan
equine encephalitis viruses. |
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