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alpha-thalassemia |
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thalassemia /thal·as·se·mia/ (thal″ah-se´me-ah) a heterogeneous group of hereditary hemolytic anemias marked by a decreased rate of synthesis of one or more hemoglobin polypeptide chains, classified according to the chain involved (α, β, δ); the two major categories are α- and β-thalassemia. α-thalassemia that caused by diminished synthesis of alpha chains of hemoglobin. The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis. The heterozygous form may be asymptomatic or marked by mild anemia. β-thalassemia that caused by diminished synthesis of beta chains of hemoglobin. The homozygous form is called t. major and the heterozygous form is called t. minor. thalassemia ma´jor the homozygous form of β, in which hemoglobin A is completely absent; it appears in the newborn period and is marked by hemolytic, hypochromic, microcytic anemia, hepatosplenomegaly, skeletal deformation, mongoloid facies, and cardiac enlargement. thalassemia mi´nor the heterozygous form of β, usually asymptomatic, although there is sometimes mild anemia. sickle cell–thalassemia a hereditary anemia involving simultaneous heterozygosity for hemoglobin S and thalassemia. Alpha-thalassemia An inherited disorder that interferes with the normal production of hemoglobin. Mentioned in: Polyhydramnios and Oligohydramnios alpha-thalassemia Etymology: Gk, thalassa, sea + haema, blood an anemia caused by a decreased rate of synthesis of the alpha chains of hemoglobin. The homozygous form is incompatible with life, the stillborn infant displaying severe hydrops fetalis; the heterozygous form may be asymptomatic or marked by mild anemia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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alpha-lipoprotein alpha-methyldopa alpha-naphthylisothiocyanate alpha-naphthylthiourea alpha-pthalic-acid esters alpha-receptor alpha-selective blockers alpha-thalassemia alpha-tocopherol alpha1-antitrypsin alpha2-antiplasmin alpha2-macroglobulin alpha2-opsonic protein alphabet, international phonetic alphadolone |
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