Excess levels of either calcium or alpha-synuclein
may be what starts the chain reaction that leads to the death of brain cells.
Colonic inflammation, alpha-synuclein
pathology in the gut, and dysbiosis of the gut microbiome in PD are among the many clues.
Aprinoia Therapeutics focuses on tau, alpha-synuclein
, and novel targets for neurodegenerative diseases.
Allele-specific polymerase chain reaction was used for screening of three pathogenic single nucleotide polymorphisms in alpha-synuclein
2006) Familial Parkinson mutant alpha-synuclein
causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
Using the team's novel analysis techniques, the researchers at HBKU will assess the product's ability to engage with the target, alpha-synuclein
Lewy bodies are abnormal deposits of a protein called alpha-synuclein
Mice with extra alpha-synuclein
acted like they had Parkinson's: They traversed a narrow beam more slowly, they couldn't grip a pole as well and they struggled to pull stickers off their noses.
Molecular basis for preventing alpha-synuclein
aggregation by a molecular tweezer.
In fact, alpha-synuclein
aggregates are the main constituent of Lewy Bodies, characteristic proteins inclusions found in parkinsonian brains.
Mutations in alpha-synuclein
are strongly linked to development of Parkinson's disease.
phosphorylation as a therapeutic target in Parkinson's disease.