alpha-synuclein


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alpha-synuclein

(ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
n.
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
Excess levels of either calcium or alpha-synuclein may be what starts the chain reaction that leads to the death of brain cells.
Colonic inflammation, alpha-synuclein pathology in the gut, and dysbiosis of the gut microbiome in PD are among the many clues.
Aprinoia Therapeutics focuses on tau, alpha-synuclein, and novel targets for neurodegenerative diseases.
Allele-specific polymerase chain reaction was used for screening of three pathogenic single nucleotide polymorphisms in alpha-synuclein gene.
2006) Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
Using the team's novel analysis techniques, the researchers at HBKU will assess the product's ability to engage with the target, alpha-synuclein.
Lewy bodies are abnormal deposits of a protein called alpha-synuclein.
Mice with extra alpha-synuclein acted like they had Parkinson's: They traversed a narrow beam more slowly, they couldn't grip a pole as well and they struggled to pull stickers off their noses.
Molecular basis for preventing alpha-synuclein aggregation by a molecular tweezer.
In fact, alpha-synuclein aggregates are the main constituent of Lewy Bodies, characteristic proteins inclusions found in parkinsonian brains.
Mutations in alpha-synuclein are strongly linked to development of Parkinson's disease.
alpha-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.