ADRA2B

(redirected from Alpha-2B adrenoceptor)

ADRA2B

A gene on chromosome 2p13-q13 that encodes alpha-2B-adrenergic receptor, a member of the G protein-coupled receptor superfamily, which plays a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the CNS, smooth muscle contraction and thermoregulation. The alpha2B subtype associates with EIF-2B, a guanine nucleotide exchange protein that regulates translation.

ADRA2A agonists
Clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine.

ADRA2A antagonists
Yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin >
alprenolol > propanolol > pindolol.
References in periodicals archive ?
Administration of dexmedetomidine in mice lacking both alpha-2A and alpha-2B receptors, failed to produce the initial hypertension, which can be attributed to the alpha-2B adrenoceptor subtype (33) and the central hypotensive effect related to the alpha-2A adrenoceptor subtype (30).
Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of alpha-2B adrenoceptors.
Activation of alpha-2B Adrenoceptors Mediates the Cardiovascular Effects of Etomidate.