alpha-2 macroglobulin


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alpha-2 macroglobulin

Plasma glycoprotein made principally by the liver that inhibits serine proteases, leukocyte elastase, and proteinase 3, but not matrix metalloproteinases.
See also: macroglobulin
References in periodicals archive ?
In addition, alfimeprase's thrombolytic activity appears to be localized to the site of delivery because it is rapidly inactivated by alpha-2 macroglobulin, a naturally occurring protein in the blood, as it moves away from the site of delivery and into the general blood circulation.
It encodes alpha-2 macroglobulin, a protein that deactivates proteases, enzymes that carve up other proteins.
In addition, its lytic activity is localized to the site of delivery due to its rapid inhibition by alpha-2 macroglobulin, a naturally occurring protein in the blood, as soon as it moves away from the clot and into the general circulation.
Alpha-2 macroglobulin levels returned to baseline within 14 days of receiving drug.

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