SERPINA1

(redirected from Alpha-1 protease inhibitor)

SERPINA1

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin and plasminogen activator, the latter three of which it irreversibly inhibits. 

Molecular pathology
SERPINA1 mutations cause pulmonary emphysema and liver disease.
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The appointed SAB will serve as a strategic resource to the company as it continues to develop and commercialize its proprietary plasma fractionation platform, Salt Diafiltration Process (SDF(TM)), and its lead biologic candidate, SDF Alpha, its proprietary alpha-1 protease inhibitor (A1PI).
Exploiting two proprietary platforms, Salt Diafiltration (SDF(TM)) Process and Polymer Hydrogel Technology (PHT(TM)), PlasmaTech is active in the development and commercialization of human plasma-derived therapeutics, including its proprietary alpha-1 protease inhibitor, SDF Alpha(TM).
Key words: alpha-1 antitrypsin deficiency, alpha-1 protease, alpha-1 protease inhibitor, genetic epidemiology, Pi phenotypes, Pi subtypes, population genetics.

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