In the ALLHAT study, diuretic drugs were compared to angiotensin-converting enzyme (ACE) inhibitors that widen blood vessels and decrease resistance, calcium channel blockers that relax vessels by slowing the flow of calcium into the heart and alpha blockers
, which also relax blood vessels.
Hypersensitivity to the particular alpha blocker
Drugs classes considered include Diuretics, Beta blockers, Alpha blockers
, Adrenergic receptor agonists, Calcium channel blockers, ACE inhibitors, Angiotensin II receptor antagonists, Statins, Aldosterone antagonists or others (specified).
The alpha blockers
did not affect uroflowmetric parametres in different voiding positions.
1 Mean percentage of patients receiving the top nine beta or alpha blockers
for the treatment of Hypertension.
In studies on combination therapy, symptom relief was maintained after withdrawal of alpha blockers
in majority of patients with moderate symptoms, whereas there was worsening experienced by the patients with severe symptoms.
There is evidence that discontinuation of an alpha blocker
after a period of combination therapy may provide durable symptom relief.
First Approved Alpha Blocker
Positioned as Less Risky
A review of 53 cases of ruptured pheochromocytoma revealed that 17 (32%) of the patients died, and that no mortality occurred among the 12 patients who received an alpha blocker
(for high blood pressure) and fluid infusion therapy before surgery.
Finasteride monotherapy maintains stable lower urinary tract symptoms in men with BPH following cessation of alpha blockers
First-generation alpha blockers
are nonselective with regard to alpha 1 adrenoreceptor subtypes and, as a result, have been associated with orthostatic hypotension," said Leonard S.
PRA has implemented REMS programs in support of novel drugs and biologicals, such as TNF alpha blockers
, as well as mature products such as antiepileptic drugs.