adrenergic receptor

(redirected from Alpha adrenergic receptor)

adrenergic receptor

Etymology: L, ad + ren, kidney; Gk, ergon, work; L, recipere, to receive
a site in a sympathetic effector cell that reacts to adrenergic stimulation. Two types of adrenergic receptors are recognized: alpha-adrenergic, which act in response to sympathomimetic stimuli, and beta-adrenergic, which block sympathomimetic activity. In general, stimulation of alpha receptors is excitatory of the function of the host organ or tissue, and stimulation of the beta receptors is inhibitory.

Adrenergic Receptor

Any of a family of G protein-coupled cell membrane receptors which receive neuronal impulses from postganglionic adrenergic fibres of the sympathetic nervous system, which are divided into:
(1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. Alpha receptors are divided into alpha1 (Gq) and alpha2 (Gi) coupled receptors.
Selective agonist, alpha receptor Phenylephrine
Alpha receptor effects Vasoconstriction, reduced GI tract motility.
(2) Beta receptors, which dampen the response to catecholamines. Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events.
Selective agonist, beta receptor Isoprenaline
Beta receptor effects Increased cardiac output, increased renin secretion from juxtaglomerular cells, increased gastric ghrelin secretion, smooth muscle relaxation resulting in bronchodilation, reduced GI motility, relaxation of detrusor muscle of the bladder, lipolysis, glycogenolysis and gluconeogenesis, increased renin secretion, insulin secretion, vasodilation, anabolism and thermogenesis of skeletal muscle.

adrenergic receptor

Neurophysiology Any of a family of cell membrane receptors that receive neuronal impulses from postganglionic adrenergic fibers from the sympathetic nervous sytem, which are divided into α receptors, which results in an excitatory response of smooth muscle cells to catecholamines, and β receptors, which result in an inhibitory response to catecholamines; the GI tract is an exception, in that either α or β receptor stimulation results in relaxation

Adrenergic receptor

There are three families of adrenergic receptors, alpha1, alpha2 and beta, and each family contains three distinct subtypes. Each of the nine subtypes are coded by separate genes, and display specific drug specificities and regulatory properties.
References in periodicals archive ?
In addition to this newly issued patent Synaptic has 16 applications pending on its alpha adrenergic receptor and benign prostatic hyperplasia technology.
In March 2000, Synaptic began making non-exclusive licenses available to companies in need of Synaptic's portfolio of intellectual property on the alpha adrenergic receptors for drug discovery.
The alpha adrenergic receptor system, which responds to the neurotransmitter adrenaline, is an important signaling mechanism in the body and is believed to be involved in such diverse therapeutic indications as cardiovascular disease, benign prostatic hyperplasia (BPH), pain and glaucoma.
Mullinix continued to comment that, "Being awarded a patent to the screening claims for the alpha adrenergic 1D receptor is yet another addition to our patent estate related to the alpha adrenergic receptor family and its use in drug discovery.
5%, an alpha adrenergic receptor agonist with a beta adrenergic receptor inhibitor, for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP.
Synaptic scientists used this technology to clone all six human alpha adrenergic receptor subtypes and to determine that the alpha 1-a adrenergic receptor subtype is a target for BPH drugs.
Non-Exclusive Licenses to Alpha Adrenergic Receptors and BPH Patents
The market scenario will change after the launch of new disease-modifying therapies such as NGF binders, transient receptor potential vanilloid (TRPV) antagonists, calcium channel blockers, non-peptide neurotoxins, alpha adrenergic receptors, p38 kinase inhibitors, fatty acid amides hydrolase inhibitors, alpha-2 delta ligands, bradykinin (B2) receptor, N-Methyl-D-aspartate (NMDA) antagonists, sigma 1 agonists and so on.
Alpha adrenergic receptors are G Protein-Coupled Receptors that are activated by the neurotransmitter norepinephrine (noradrenaline).
These trials confirmed the Company's discovery that, of the three alpha adrenergic receptors, the alpha 1-a receptor is an appropriate target for BPH.
including the prostanoid and alpha adrenergic receptors.