orlistat(redirected from Alli (drug))
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Pharmacologic class: GI lipase inhibitor
Therapeutic class: Weight control drug
Pregnancy risk category X
Inhibits absorption of dietary fats in stomach and small intestine
Capsules: 60 mg (over-the-counter drug), 120 mg
⊘Indications and dosages
➣ Obesity management (in conjunction with reduced-calorie diet); to reduce risk of regaining after weight loss
Adults: 120 mg (Xenical) P.O. t.i.d. with each main meal containing fat (during or up to 1 hour after the meal)
➣ Weight loss in overweight adults (in conjunction with reduced-calorie and low-fat diet)
Adults ages 18 and older: 60 mg (Alli) P.O. t.i.d. with each meal containing fat
• Hypersensitivity to drug or its components
• Chronic malabsorption syndrome or cholestasis
• Patients who have had organ transplant or are taking drugs to reduce organ rejection (such as cyclosporine), patients with known problems absorbing food (Alli)
Use cautiously in:
• hypothyroidism, nephrolithiasis, diabetes mellitus, clinically significant GI disease, fat-soluble vitamin deficiencies
• history of bulimia or anorexia nervosa
• breastfeeding patients
• Know that organic causes of obesity should be ruled out before therapy starts.
• Give three times daily with meal containing fat (Alli) or up to 1 hour after a meal (Xenical).
• If patient misses a meal or eats a fat-free meal, omit dose.
• Know that orlistat therapy is frequently combined with psychotherapy.
CNS:Xenical: dizziness, headache, fatigue, insomnia, depression, anxiety
EENT:Xenical: ear, nose, and throat symptoms
GI: fecal urgency, flatus with discharge, oily or increased bowel movements, oily spotting, fecal incontinence
GU:Xenical: urinary tract infection (UTI), vaginitis, menstrual irregularities
Hepatic: severe liver injury (rare)
Musculoskeletal:Xenical: back pain, arthritis, myalgia, tendinitis
Respiratory:Xenical: upper or lower respiratory infection
Skin:Xenical: dry skin, rash
Other:Xenical: dental pain, tooth disorder, influenza
Drug-drug.Beta-carotene, fat-soluble vitamins: reduced vitamin absorption
Cyclosporine: reduced cyclosporine blood level (Xenical)
Pravastatin: increased lipid-lowering effects (Xenical)
Warfarin: altered coagulation parameters
☞ Monitor hepatic function closely. If liver injury is suspected, discontinue drug immediately and continue to monitor liver function tests.
• Watch for signs and symptoms of UTI, respiratory infection, and EENT disorders.
• Monitor patient for weight loss.
• Evaluate patient's diet for appropriate caloric intake.
• Be aware that patient may develop an elevated urinary oxalate level. Monitor renal function in patients at risk for renal insufficiency.
• Instruct patient to take with meals as directed. Tell him he may omit a dose if he misses a meal or eats a fat-free meal.
• Advise patient to consume reduced-calorie diet and to spread daily fat intake over three main meals.
• Inform patient that drug predisposes him to EENT, respiratory, and urinary infections. Instruct him to promptly report signs and symptoms.
☞ Instruct patient to report signs or symptoms of hepatic dysfunction (anorexia, pruritus, jaundice, dark urine, light-colored stools, or right upper quadrant pain).
• Tell patient about common adverse GI reactions, including problems controlling bowel movements. If significant GI upset occurs, encourage him to consult prescriber about taking psyllium at bedtime or with each dose.
• Advise patient to ask prescriber if he should take a daily multivitamin containing vitamins A, D, E, K, and beta-carotene at least 2 hours before or after taking drug.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.
orlistat/or·li·stat/ (or´lĭ-stat) an inhibitor of gastrointestinal lipases that prevents the digestion, and therefore absorption, of dietary fat; used in the treatment of obesity.
orlistatAn agent used to treat obesity, which interferes with pancreatic lipase and allows up to one-third of ingested fat to pass undigested through the GI tract.
orlistatXenical® An anti-obesity therapy which interferes with pancreatic lipase, and allows up to1⁄3 of ingested fat to pass undigested; orlistat therapy results in a modest–10% loss of weight Adverse effects Loose greasy stools. See Obesity. Cf Olestra.
orlistatAn anti-obesity pill that acts in the intestine by inhibiting the action of intestinal fat-splitting enzymes (lipases) so that up to one third of dietary fat is excreted in the faeces. Orlistat was approved by the Food and Drug Administration (FDA) in 1997.
orlistata drug which in conjunction with dieting has been proven to produce weight loss. It is a pancreatic lipase inhibitor which prevents fat breakdown in the intestine and therefore its absorption. About a third of ingested fat is passed through the bowel undigested when on a course of orlistat, reducing energy intake. Other beneficial effects include a lowering of serum cholesterol, reduction in blood pressure and better control of diabetes. Undesirable effects are abdominal discomfort, diarrhoea and anal leakage, and potential loss of fat-soluble vitamins. See also lipolysis.
drug class: lipase inhibitors;
action: interferes with the body's ability to digest fat but may cause gas and oily bowel movements;
uses: reduction in fat absorption for weight loss.