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alkylation
(redirected from Alkylating agents)

    Also found in: Encyclopedia, Wikipedia 0.03 sec.
alkylation /al·kyl·a·tion/ (al″kĭ-la´shun) the substitution of an alkyl group for an active hydrogen atom in an organic compound.
al·kyl·a·tion (lk-lshn)
n.
A process in which one or more alkyl groups are substituted for hydrogen atoms in an organic compound.
alkylation,
a chemical reaction in which an alkyl group is transferred from an alkylating agent. When such organic reactions occur with a biologically significant cellular constituent such as deoxyribonucleic acid, they result in interference with mitosis and cell division.


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Alkylating agents are highly reactive chemicals that introduce alkyl groups into biologically active molecules and prevent normal functioning.
MIT toxicogenomics research program by Eubanks, Mary / Environmental Health Perspectives
Using these and other factors, the retrospective study of more than 9,000 patients provides strong statistical evidence that approximately half of the secondary bone cancers observed can be blamed on radiation therapy or on chemotherapeutic alkylating agents such as the frequently prescribed cyclophosphamide.
Cancer therapy risks assessed by Weiss, Rick / Science News
Drug Interactions Immunosuppressive therapies including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to vaccines.
Merck Updates Prescribing Information for ROTATEQ(R), the Company's ... by Business Wire
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