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alglucerase |
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alglucerase /al·glu·cer·ase/ (al-gloo´ser-ās″) a form of β-glucocerebrosidase used to replace glucocerebrosidase (glucosylceramidase) in the treatment of the adult form of Gaucher's disease. alglucerase Ceredase® A monomeric 497 AA glycoprotein and modified form of β-glucerebrosidase, which catalyzes the hydrolysis of glucocerebroside in reticuloendothelial system lysosomes, which is produced by genetic
engineering; alglucerase is the most effective therapy for type 1 Gaucher disease, resulting in ↓ hepatospenomegaly, hematologic defects, ↑ bone mineralization, and reversal of cachexia Cost Very high. See Gaucher disease, 'Orphan
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