Corticosteroids, retinoids, dapsone, methotrexate, biologics such as alefacept
, cyclosporine and thalidomide are the systemic agents used in the treatment of HHD.
In addition, a couple of other molecules, rhIL-2 and alefacept
(Amevive), are under investigation, he said.
Satisfactory results have been reported in a limited number of patients with severe OLP that were treated with the anti T-cell agents such as alefacept
Disseminated systemic Nocardia farcinica infection complicating alefacept
and infliximab therapy in a patient with severe psoriasis.
Currently, four conventional systemic agents: Cyclosporin A, methotrexate, fumaric acid esters (Germany only), and acitretin, and five biological agents: Infliximab, etanercept, adalimumab, alefacept
(United States and Switzerland only), and ustekinumab are approved for chronic plaque psoriasis.
is a bivalent recombinant fusion protein composed of the first extracellular domain lymphocyte function antigen 3 (LFA-3), fused to the hinge domain of human IgG1.
protects the immune system, the drug helps the body produce its own insulin, which is key for people who are suffering from type one diabetes.
23 ( ANI ): A drug, Alefacept
, which is used for treating skin disorder, Psoriasis, has shown promising results for treating some aspects of type 1 diabetes.
She was then started on a 12-week course of the biologic agent alefacept
and UVB treatment, which produced a moderate response.
binds CD2 on memory-effector T lymphocytes, inhibiting activation.
(Amevive), injected in a doctor's office once a week for 12 weeks
Hsu acknowledged that the guidelines are a bit bold because they directly state, for example, that acitretin doesn't work well for plaque psoriasis, and that evidence is scant to support the use of alefacept
to achieve full clearance.