aldosterone (redirected from Aldosterone antagonist)

aldosterone /al·dos·ter·one/ (al-dos´ter-ōn) the major mineralocorticoid hormone secreted by the adrenal cortex. It promotes the retention of sodium and bicarbonate, the excretion of potassium and hydrogen ions, and the secondary retention of water. Large excesses can invoke plasma volume expansion, edema, and hypertension.

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al·dos·ter·one (l-dst-rn)

n.

A steroid hormone secreted by the adrenal cortex that regulates the salt and water balance in the body.

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Aldosterone

A hormone secreted by the adrenal glands that is important for maintaining salt and water balance in the body.

Mentioned in: Congenital Adrenal Hyperplasia

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aldosterone

[al′dōstərōn′, aldos′tərōn]

a mineralocorticoid steroid hormone produced by the adrenal cortex with action in the renal tubule to retain sodium, conserve water by reabsorption, and increase urinary excretion of potassium.

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aldosterone [al-dos´ter-ōn, al´do-ster-ōn″]

the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.

aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

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aldosterone (al·dsˑ·t·rōn),

n an adrenal hormone that causes elevation of blood pressure through the retention of sodium and the resultant increase in blood plasma volume.

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aldosterone (aldos´trōn),

n an adrenal corticosteroid hormone that acts primarily to accelerate the exchange of potassium for sodium in the renal tubules and other cells. It is a potent mineralocorticoid but also has some regulatory effect on carbohydrate metabolism.

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aldosterone

the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II. Deficiency is hypoadrenocorticism (Addison's disease).

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aldosterone

Endocrinology An adrenocortical mineralocorticoid hormone that controls the body's electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+ ions, and maintaining BP and blood volume; aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if ↑, evokes secretion of aldosterone; ↓ Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating HTN; aldosterone is ↑ in adrenocortical adenoma or CA, bilateral adrenal hyperplasia, renovascular HTN, liver disease, CHF, cirrhosis, nephrotic syndrome, pregnancy–3^rd trimester; it is ↓ in 1º hypoaldosteronism, salt-losing syndrome, toxemia of pregnancy, Addison's disease Ref range Serum, ≤ 20 mg/dL; ≤ 20mg/24hrs, urine. See Hypertension, Pseudoaldosterone, Timed collections.