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aldose reductase inhibitor |
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aldose reductase inhibitor Clinical therapeutics Any of a family of compounds–eg, epalrestat, ponalrestat, sorbinil, tolrestat, which block aldose reductase; ↑ intracellular glucose leads to ↑ sorbitol, which competitively
inhibits glomerular and neural synthesis of myo-inositol; the ↓ in myo-inositol synthesis depresses phosphoinositide metabolism, and ↓ in Na+K+-ATPase activity; ARIs do not prevent the complications of type 1 DM See Aldose
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| ? Mentioned in | ? References in periodicals archive | |
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-- Zenarestat is an aldose reductase inhibitor licensed from
Fujisawa for the prevention of diabetic neuropathy. ZD5522 - an aldose reductase inhibitor - for neuropathy in
diabetes. |
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