aldolase(redirected from Aldehyde lyases)
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Related to Aldehyde lyases: Isomerases, Ligases
1. Generic term for aldehyde-lyase.
2. Name sometimes applied to fructose-1,6-bisphosphate aldolase.
2. an enzyme that acts as a catalyst in the production of dihydroxyacetone phosphate and glyceraldehyde phosphate from fructose 1,6-bisphosphate. It occurs in several isozymes, one of which is deficient in hereditary fructose intolerance.
Any of a class of enzymes that reversibly catalyze the cleavage of carbon-carbon bonds, especially the cleavage of sugars into three-carbon fragments during glycolysis.
enzyme found in muscle tissue that catalyzes the step in anaerobic glycolysis involving the breakdown of fructose 1,6-biphosphate to glyceraldehyde 3-phosphate. The enzyme can also catalyze the reverse reaction. Normal adult findings are 3 to 8.2 Sibley-Lehninger units/dL or 22 to 59 mU at 37° C. See also glycolysis.
aldolaseClinical chemistry A serum enzyme that cleaves fructose 1,6-diphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate in the muscles to produce energy; aldolase is distributed in all tissues and ↑ in skeletal muscle disease or injury, metastatic CA, CML, megaloblastic anemia, hemolytic anemia, or infarction; it is measured in suspected myopathies, as the intensity of ↑ reflects the severity of disease; aldolase may also be ↑ early in Pts who later develop muscular dystrophy and can also be used to monitor steroid therapy in inflammatory myopathies Ref range 3.1-7.5 U/L; aldolase is ↑ in Duchenne's muscular dystrophy, dermatomyositis, polymyositis, trichinosis
An enzyme, found primarily in the muscle, that helps convert sugar into energy.
Mentioned in: Aldolase Test
an enzyme involved in the Embden-Meyerhof or glycolytic pathway which reversibly catalyzes the reaction fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Present in all cells and may be measured in the serum as an indicator of muscle, heart or liver disease. Called also ALS and ALD.