Alcohol Flush Reaction

Also found in: Wikipedia.
A condition caused by the incomplete metabolism of alcohol with accumulation of acetaldehyde due to a missense polymorphism in acetaldehyde dehydrogenase—ALDH2—resulting in bright red skin due to capillary dilation of face, neck, shoulder, and sometimes the entire body after consuming alcohol. Those with ALDH2 deficiency have up to a 10-fold greater risk of oesophageal cancer, attributed to the accumulation of acetaldehyde
References in periodicals archive ?
When asked why people of Asian descent tended to suffer from alcohol flush reaction, Rowe added, "Most Caucasians have two copies of the ALDH2 gene, which is involved in processing alcohol in the body, whereas approximately 50% of Asian people have only one copy, resulting in a deficiency that makes it difficult for the body to process alcohol.
In a recent study, Goldwin Health found that after taking AF Formula each day for 25 days, 91% of test participants stopped experiencing alcohol flush reaction when they drank alcohol.
Washington, Jan 20 (ANI): Chinese researchers hold rice responsible for the alcohol flush reaction, an unpleasant response to alcohol that is relatively common in people of Asian descent.
Writing in the open access journal BMC Evolutionary Biology, the researchers believe that the mutation responsible for the alcohol flush reaction may have occurred following the domestication of rice.
KEY WORDS: Alcohol and other drug (AOD) use (AODU), abuse and dependence; alcoholism; genetics and heredity; genetic theory of AODU; ethnic group; protective factors; ethanol metabolism; liver; alcohol dehydrogenase (ADH); aldehyde dehydrogenase (ALDH); risk factors; protective factors; alcohol flush reaction