Alcohol Flush Reaction

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A condition caused by the incomplete metabolism of alcohol with accumulation of acetaldehyde due to a missense polymorphism in acetaldehyde dehydrogenase—ALDH2—resulting in bright red skin due to capillary dilation of face, neck, shoulder, and sometimes the entire body after consuming alcohol. Those with ALDH2 deficiency have up to a 10-fold greater risk of oesophageal cancer, attributed to the accumulation of acetaldehyde
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When asked why people of Asian descent tended to suffer from alcohol flush reaction, Rowe added, "Most Caucasians have two copies of the ALDH2 gene, which is involved in processing alcohol in the body, whereas approximately 50% of Asian people have only one copy, resulting in a deficiency that makes it difficult for the body to process alcohol.
In a recent study, Goldwin Health found that after taking AF Formula each day for 25 days, 91% of test participants stopped experiencing alcohol flush reaction when they drank alcohol.
Washington, Jan 20 (ANI): Chinese researchers hold rice responsible for the alcohol flush reaction, an unpleasant response to alcohol that is relatively common in people of Asian descent.
Writing in the open access journal BMC Evolutionary Biology, the researchers believe that the mutation responsible for the alcohol flush reaction may have occurred following the domestication of rice.
Table 1 Some causes of facial erythema Atopic eczema Seborrhoeic eczema Sebopsoriasis Allergic contact dermatitis Irritant dermatitis Photocontact dermatitis Rosacea Lichen planus Lichen planus actinicus Carcinoid Glutamate sensitivity Table 1 Some causes of facial erythema Diabetic rubeosis Topical steroids Alcohol flush 'Weather beating' Mitral stenosis Poikiloderma Rothmund-Thomsen Sarcoid Lupus erythematosus Dermatomyositis Pemphigus foliaceus Erysipelas Hansenosis Lymphoma Haemangioendothelioma Keratosis rubra faciei of Brocq Ulerythema ophryogenes Erythrose peribuccale of Brocq Riehl's melanosis Perioral dermatitis Erythromelanosis faciei et colli
KEY WORDS: Alcohol and other drug (AOD) use (AODU), abuse and dependence; alcoholism; genetics and heredity; genetic theory of AODU; ethnic group; protective factors; ethanol metabolism; liver; alcohol dehydrogenase (ADH); aldehyde dehydrogenase (ALDH); risk factors; protective factors; alcohol flush reaction
People carrying an ALDH2*2 allele show an alcohol flush reaction, even when they consume only relatively small amounts of alcohol (Peng et al.
KEY WORDS: Alcohol use disorder; alcohol and other drug (AOD)-related (AODR) mortality; AOD use, abuse, and dependence; alcoholism; East Indians; Native American; Southwest California Indians; genetic factors; genetic polymorphisms; protective factors; alcohol flush reaction; ethanol metabolism; alcohol dehydrogenase (ADH); aldehyde dehydrogenase (ALDH); acetaldehyde; ALDH1; ALDH2; ALDH2*2; ALDH1A1*2; ADH1B; ADH1B*3
KEY WORDS: Alcohol and other drug (AOD) use, abuse, and dependence; drinking behavior; African American; ethanol metabolism; alcohol dehydrogenase (ADH); aldehyde dehydrogenase (ALDH); acetaldehyde; genetic factors; genetic polymorphisms; allele; ADH1B; ADH1B*3; ALDH1A1*2; ALDH1A1*3; protective factors; alcohol flush reaction
KEY WORDS: Ethanol metabolism; ethanol-to-acetaldehyde metabolism; acetaldehyde; aldehyde dehydrogenases (ALDHs); alcohol dehydrogenase (ADH); alcohol metabolite; catalase; brain; central nervous system; protective factors; alcohol flush reaction; pharmacology and toxicology
KEY WORDS: ethnic differences; minority group; cultural patterns of drinking; female; African American; Asian American; Hispanic; Native American; spiritual and religious regulation of behavior; AOD (alcohol and other drug) abstinence; protective factors; risk factors; alcohol flush reaction; acculturation; cultural conflict; literature review