Ah receptor


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Ah receptor

A receptor that is detectable in many tissues and organs which binds various environmental pollutants, including polycyclic aromatic hydrocarbons, hetercyclic amines and polychlorinated aromatic compounds (e.g., dioxins, dibenzofurans and biphenyls), and mediates the well-known carcinogenic effects of these agents. Once bound via a helix-loop-helix motif and activated, the Ah receptor-ligand complex is transported to the nucleus where it binds to specific DNA sequences and variously turns genes on or off.
References in periodicals archive ?
Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats.
Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits.
However, green tea now seems to be the best drink-based defence as it also contains chemicals which `shut down' the action of a molecule known as the AH receptor, which plays a key role in the development of tumours.
The aromatic hydrocarbon (Ah) gene battery (1) comprises Ah receptor (AHR), its nuclear translocator (ARNT), and the genes that encode the detoxifying enzymes of phase I (e.
The study of compounds that interact with the Ah receptor has resulted in the identification of compounds with useful therapeutic properties.
These so-called knockout mice proved sickly, suggesting that the body needs the Ah receptor for healthy development (SN: 5/6/95, p.
com/research/30dc32/the_ah_receptor_in) has announced the addition of John Wiley and Sons Ltd's new book "The AH Receptor in Biology and Toxicology" to their offering.
Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor.
This patent relates to new, improved and user-friendly methods of detecting dioxin-like compounds by detecting the transformed Ah receptor," said the inventor and Senior Scientist at Paracelsian, Dr.
Now, toxicologists at the University of California, Davis report that carbaryl, one of the most widely used insecticides, turns on the Ah receptor in liver cells despite having a shape remarkably unlike dioxins.
The initial step in dioxin toxicity requires the binding to, and transformation of the Ah receptor to a DNA-binding form that then affects the expression of several gene products.
Initially, we will make an effort to secure value-added partnerships to accomplish three goals: 1) development of antiviral therapies based on the Company's Ah receptor patent and its Andrographolide patent, 2) screening of the Company's herbal extracts and the development of active extracts into potential therapeutic agents, and 3) evaluation of the Company's CDK assays as diagnostic and prognostic tools in cancer diagnosis and treatment," added Dr.