agnogenic myeloid metaplasia

agnogenic myeloid metaplasia.

See myeloid metaplasia.

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agnogenic

of unknown origin.

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agnogenic myeloid metaplasia

see myeloid metaplasia.

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agnogenic myeloid metaplasia

Myelofibrosis with myeloid metaplasia Hematology A chronic progressive condition–panmyelosis and variable BM fibrosis, massive splenomegaly 2º to extramedullary hematopoiesis and leukoerythroblastic anemia with dysmorphic RBCs, circulating normoblasts, immature WBCs, atypical platelets Clinical Pts are often > age 50, insidious weight loss, anemia, abdominal discomfort due to splenomegaly, often with hepatomegaly; 80% have nonspecific chromosome defects Diagnosis BM Bx Management No specific therapy; packed RBCs for anemia, androgens may ↓ transfusion requirements, but are poorly tolerated in ♀; recombinant erythropoietin Prognosis Survival ± 5 yrs, often → acute leukemia. See Pseudonym syndrome.