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dipyridamole |
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dipyridamole /di·py·rid·a·mole/ (di″pĭ-rid´ah-mōl) a platelet inhibitor and coronary vasodilator used to prevent thromboembolism associated with mechanical heart valves, to treat transient ischemic attacks, and as an adjunct in preventing myocardial reinfarction and in myocardial perfusion imaging.
dipyridamole [dī′pirid′əmōl] an antiplatelet agent. indication When used in combination with coumarin anticoagulants, it is used to prevent postoperative thromboembolic complications of cardiac valve replacement. contraindications It should be used with caution in hypotension. adverse effects The adverse reactions are mild and transient, such as headache, dizziness, rash, nausea, and flushing. dipyridamole [di″pi-rid´ah-mōl] a platelet inhibitor and coronary vasodilator, used to prevent clotting associated with mechanical heart valves and to treat transient ischemic attacks. It is also used as an adjunct in the prevention of myocardial reinfarction and as an adjunct in radionuclide myocardial perfusion imaging.
dipyridamole (dīpir´id
n brand name: Persantine; drug class: platelet aggregation inhibitor; action: specific action unclear; inhibits ability of platelets to aggregate; uses: prevention of transient ischemic attacks (TIA), inhibition of platelet aggregation to prevent myocardial reinfarction, prevention of coronary bypass graft occlusion with aspirin. dipyridamole a coronary vasodilator with antiplatelet activity.
dipyridamole Apo-Dipyridamole FC (CA), Apo-Dipyridamole SC (CA), Novo-Dipiradol (CA), Persantin (UK), Persantine Pharmacologic class: Platelet adhesion inhibitor Therapeutic class: Antiplatelet agent, diagnostic agent (coronary vasodilator) Pregnancy risk category B ActionUnclear. May reduce platelet aggregation by inhibiting phosphodiesterase, adenosine uptake, or formation of thromboxane A2. Produces vasodilation, thereby increasing coronary blood flow. AvailabilityInjection: 10 mg/2 ml Tablets: 25 mg, 50 mg, 75 mg, 100 mg ⊘Indications and dosages ➣ To prevent thromboembolism in patients with prosthetic heart valves Adults: 75 to 100 mg P.O. q.i.d. ➣ Alternative to exercise in thallium myocardial perfusion imaging Adults: 0.57 mg/kg I.V. infused over 4 minutes (0.142 mg/kg/minute). Maximum I.V. dosage is 60 mg. Off-label uses• Prevention of myocardial reinfarction (given with aspirin) Contraindications• Hypersensitivity to drug PrecautionsUse cautiously in: Administration• Know that drug is usually given with warfarin when used to prevent thromboembolism.
Adverse reactionsCNS: dizziness, headache, syncope; transient cerebral ischemia or weakness (with I.V. use) CV: hypotension, arrhythmias, myocardial infarction (all with I.V. use) GI: nausea, vomiting diarrhea, dyspepsia Hematologic: prolonged bleeding time Respiratory: bronchospasm (with I.V. use) Skin: rash, flushing (with I.V. use) InteractionsDrug-drug. Anticoagulants, cefamandole, cefoperazone, cefotetan, nonsteroidal anti-inflammatory drugs, plicamycin, sulfinpyrazone, thrombolytics, valproic acid: increased risk of bleeding Aspirin: increased effect on platelet aggregation Theophylline: negation of dipyridamole effects during thallium imaging Drug-behaviors. Alcohol use: increased risk of hypotension Patient monitoring• Monitor for therapeutic efficacy, including improved exercise tolerance and decreased need for nitrates. Patient teaching• Advise patient to take drug 1 hour before or 2 hours after meals for best absorption. Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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