ADAMTSaf5

(redirected from Aggrecanase-2)

ADAMTSaf5

An ADAMTSs family enzyme encoded by ADAMTS5 on chromosome 21q21.3 which, like ADAMTS4, cleaves aggrecan, the major proteoglycan of cartilage. It is highly expressed in placenta and appears to play a role in proteolytic processing during the peri-implantation period. It may be upregulated in arthritic diseases.
References in periodicals archive ?
It is also suggested that another enzyme, aggrecanase-2, or ADAMTS-5 (a disintegrin and MMP domain with thrombospondin motifs), plays a predominant role in the proteolysis of OA cartilage aggrecan.