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tirofiban
(redirected from Aggrastat)

   Also found in: Wikipedia 0.01 sec.
tirofiban /ti·ro·fi·ban/ (ti″ro-fi´ban) a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves.
tirofiban,
an antiplatelet agent.
indication It is used to treat acute coronary syndrome.
contraindications The following factors prohibit its use: known hypersensitivity to this drug, active internal bleeding, stroke, major surgery, severe trauma, intracranial neoplasm, aneurysm, and hemorrhage.
adverse effects Bleeding is a life-threatening effect of tirofiban. Other adverse reactions include bradycardia, dizziness, dissection, coronary artery edema, pain in the legs and/or pelvis, and sweating. Rash is a common side effect.

tirofiban [ti″ro-fi´ban]
a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves; administered intravenously.

tirofiban
Aggrastat®, MK-383 Cardiology A potent short-acting, nonpeptide inhibitor of platelet glycoprotein IIb/IIIa or integrin αIIbβ3 receptor which, when administered with heparin, ↓ ischemic events in Pts with acute coronary syndrome. See PRISM, PRISM-PLUS.


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In addition, a licensing agreement was concluded with US-based Iroko Pharmaceuticals for the distribution of three Merck, Sharpe & Dohme products including Aldomet, Indocid and Aggrastat.
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