amprenavir

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Related to Agenerase: Invirase, Aptivus

amprenavir

 [am-pren´ah-vir]
an HIV protease inhibitor used in the treatment of human immunodeficiency virus (HIV) infection; administered orally.

amprenavir

/am·pren·a·vir/ (am-pren´ah-vir) an HIV protease inhibitor used in the treatment of HIV-1 infection.

amprenavir

an antiviral (protease inhibitor).
indication It is used to treat HIV in combination with other antiretroviral agents.
contraindication Known hypersensitivity prohibits its use.
adverse effects Life-threatening side effects include Stevens-Johnson syndrome and acute hemolytic anemia. Other serious adverse effects include new-onset diabetes, hyperglycemia, and exacerbation of preexisting diabetes mellitus. Common side effects include diarrhea, abdominal pain, nausea, paresthesia, and rash.

amprenavir

A protease inhibitor used with other antiretrovirals for managing HIV-1 (e.g., nelfinavir, indinavir or saquinavir).

Adverse effects
Nausea, vomiting, diarrhoea, headache, perioral paraesthesias, gastric discomfort, rash, hyperglycaemia, diabetes, acute haemolytic anaemia, spontaneous bleeding in haemophiliacs, fat redistribution.

amprenavir

AIDS A protease inhibitor in clinical trials for treating HIV, used in combination with other protease inhibitors–eg, nelfinavir, indinavir, or saquinavir Adverse effects N&V, diarrhea, headache, perioral paresthesias, stomach discomfort, rash; other effects include hyperglycemia, DM, acute hemolytic anemia, spontaneous bleeding in hemophiliacs, and fat redistribution. See AIDS, Combination therapy, HIV, Protease inhibitor.

amprenavir

A protease inhibitor drug used to treat HIV infections. A brand name is Agenerase.
References in periodicals archive ?
COLUMN A COLUMN B Agenerase Retrovir plus Hivid Fortovase Videx plus Epivir Norvir Rescriptor Viracept plus Fortovase Viramune Ziagen
TABLE: Currently approved medications for treating HIV/AIDS Protease Entry Nukes Non-nukes Inhibitors Inhibitors Combivir Rescriptor Agenerase Fuzeon (Epivir + Retrovir) Emtriva Sustiva Crixivan Epivir Viramune Fortovase Hivid Invirase Retrovir Kaletra Trizivir (Epivir + Lexiva Retrovir + Ziagen) Videx (regular or EC) Norvir Viread Reyataz Zerit Viracept Ziagen
On February 5, 2002, FDA approved a new dosing regimen for Agenerase (amprenavir) and Norvir (ritonavir) used in combination.
The reason this drug is important is that the current version of Agenerase requires taking 16 large capsules a day.
purchased, the Company's right to receive future royalty payments, net of sub-royalty payments due to a third party, arising from sales of Lexiva/Telzir and Agenerase under the Company's 1993 license agreement with GlaxoSmithKline plc for periods commencing April 1, 2008, in return for a one-time cash payment of $160.
First, taking Agenerase and Methadone is not recommended because Agenerase lowers the levels of Methadone in the blood, and Agenerase may not be absorbed as well when taken with Methadone.
0 million for sale of the Company's rights to future royalties of the HIV protease inhibitors Lexiva/Telzir and Agenerase under the Company's 1993 license agreement with GlaxoSmithKline plc.
2003, has shown to be similar in efficacy to AGENERASE, but offers a number of dosing benefits over AGENERASE.
The study was done to see if the combination of the two drugs would help reduce the number of Agenerase pills required per day (16 large pills).
As a result of the sale of the future royalties, Vertex will no longer make royalty payments to the third party with respect to Lexiva and Agenerase.
When the two are used in combination, 1200 mg of Agenerase can be given with 200 mg of Norvir once a day, or 600 mg of Agenerase can be given with 100 mg of Norvir twice a day.
The drug, sold by GlaxoSmithKline (NYSE: GSK), has a convenient dosing and favorable metabolic profile relative to first-generation protease inhibitors such as Agenerase, Crixivan, and Viracept.