African histoplasmosis caused by Histoplasma capsulatum var.
duboisii is also known as African histoplasmosis because it has only been described on that continent, mostly in central and western Africa.
The pathogenesis of African histoplasmosis remains unclear.
Despite its rarity, African histoplasmosis should be kept in mind as a diagnosis in Africa-born patients or travelers to sub-Saharan West and central Africa who have compatible signs or symptoms, even if they are HIV-infected, because the saprophytic phase of this dimorphic fungus should be manipulated in a Biosafety Level 3 cabinet.
Treatment of African histoplasmosis can be extrapolated from the guidelines of the Infectious Diseases Society of America established for histoplasmosis due to variety caspulatum (29).
Is African histoplasmosis an opportunistic fungal infection in AIDS?