Aerolysin

Aerolysin

A 54 kD cytolytic toxin produced by Aeromonas hydrophila, a gram-negative bacterium which causes gastroenteritis and deep wound infections. Aerolysin binds to eukaryotic (host) cells and aggregates to form a ±3 nm in diameter transmembrane ion channel, leading to the destruction of the membrane permeability barrier and osmotic lysis.
References in periodicals archive ?
It is known that aerolysin, a PFT from Aeromonas hydrophila with structural and functional similarity to VCC, depends critically for its association with lipid rafts for insertion into the bilayer to generate a functional channel (23).
Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin.
The licence grants Protox the worldwide rights to commercialize a genetically modified Aerolysin protein developed by the research institutions as a targeted therapy for the treatment of prostate cancer.
Buckley and the other members of Protox management in taking the Aerolysin technology from the lab to commercial applications.