Werner syndrome

(redirected from Adult premature aging syndrome)
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Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Wer·ner syn·drome

(wĕr'nĕr), [MIM*277700]
a premature aging disorder presenting sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Werner syndrome

(vĕr′nər) or

Werner's syndrome

(-nərz)
n.
An autosomal recessive disorder characterized by short stature and the appearance of premature aging after puberty, with early development of conditions such as cataracts, cardiovascular disease, osteoporosis, and malignancies.

Werner syndrome

A rare autosomal recessive progeroid syndrome (OMIM:277700) characterised by premature onset of multiple age-related disorders, including atherosclerosis, cancer, type-2 diabetes, ocular cataracts, osteoporosis, and death by age 47, often due to myocardial infarction.

Molecular pathology
Defects of WRN, which encodes a DNA helicase responsible for maintaining genomic integrity, cause Werner syndrome.

Wer·ner syn·drome

(ver'ner sin'drōm)
A premature aging disorder consisting of sclerodermalike skin changes, bilateral juvenile cataracts, progeria, hypogonadism, and diabetes mellitus; autosomal recessive inheritance, caused by mutation in the WRN gene, which encodes a helicase protein on chromosome 8p.

Werner,

Otto, German physician, 1879-1936.
Werner disease - hereditary disorder characterized by premature aging. Synonym(s): progeria adultorum; Werner syndrome
Werner syndrome - Synonym(s): Werner disease
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