adrenocortical carcinoma

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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
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References in periodicals archive ?
Liposarcoma is extremely rare and is usually recognized as adrenocortical cancer because of its large volume.
Retrospective evaluation of the outcome of open versus laparoscopic adrenalectomy for stage I and II adrenocortical cancer.
One such event was the loss of Millie Schembechler, the wife of Bo Schembechler, to adrenocortical cancer in 1986.
Following a review of DCE-MRI data from 10 patients with N-cadherin positive tumors and 12 patients with N-cadherin negative tumors, the Company noted changes in Ktrans, a measure of blood flow to the tumor and other related parameters such as vascular permeability and interstitial tumor pressure, in three patients with N-cadherin positive tumors, including two with renal cancer and one with adrenocortical cancer, who also experienced the hormonal response described earlier.