adrenocortical carcinoma

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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
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