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The results were indeed surprising, far beyond expectation, because the CPV transcriptase activity was stimulated nearly 100-fold, and mRNA synthesis appeared to proceed in an AdoMet
dependent manner (Fig.
Met is converted into AdoMet
by catalytic actions of two isoenzymes, MATI and MATIII, of methionine adenosyl transferase [2, 3].
It has been established that ethylene is biosynthesized from methionine via AdoMet
and 1-aminocyclopropane-1-carboxylate (ACC) (Zeng et al.
After donation of the activated methyl group to an acceptor, AdoMet
is converted into total Hcy by formation of S-adenosyl-L-homocysteine (AdoHcy) (10).
June 1999), reported that "longterm treatment with ADoMet
[SAM] may improve survival or delay liver transplantation in the patients with alcoholic liver cirrhosis, especially in those with less advanced liver disease.
Por otra parte, se conoce que las poliaminas y el etileno tienen un intermediario comun en su ruta metabolica, la metionina, precursor directo de la AdoMet
(S-adenosilmetionina) que es el donador metil primario en las reacciones de transmetilacion y participa en la biosintesis de ambos, poliaminas y etileno (Onouchi et al.
Terms: (A) ACC synthase (B) AdoMet
(C) ACC oxidase (D) ACC
The demethylated product of AdoMet
is S-adenosylhomocysteine (AdoHcy), which is hydrolyzed to homocysteine and adenosine in a reversible reaction catalyzed by AdoHcy hydrolase.
In terms of synthesis, his group has developed new methods for the preparation of methionine and AdoMet
analogues as well as aminosugars.
In addition, the metabolites, AdoMet
and AdoHcy are responsible for activating and inhibiting many enzymes, which makes the cycle more complex.
/AdoHcy ratio is a more important determinant of cellular methylation potential than the is absolute amount of AdoMet