adjuvant

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adjuvant

 [aj´ah-vant, ă-joo´vant]
1. assisting or aiding.
2. a substance that aids another, such as an auxiliary remedy.

ad·ju·vant

(ad'jū-vănt),
1. A substance added to a drug product formulation that affects the action of the active ingredient in a predictable way.
2. immunology a vehicle used to enhance antigenicity; for example, a suspension of minerals (alum, aluminum hydroxide, or phosphate) on which antigen is adsorbed; or water-in-oil emulsion in which antigen solution is emulsified in mineral oil (Freund incomplete adjuvant), sometimes with the inclusion of killed mycobacteria (Freund complete adjuvant) to enhance antigenicity further (inhibits degradation of antigen and/or causes influx of macrophages).
3. Additional therapy given to enhance or extend primary therapy's effect, as in chemotherapy's addition to a surgical regimen.
4. A treatment added to a curative treatment to prevent recurrence of clinical cancer from microscopic residual disease.
[L. ad-juvo, pres. p. -juvans, to give aid to]

adjuvant

/ad·ju·vant/ (aj″dbobr-vant) (ă-joo´vant)
1. assisting or aiding.
2. a substance that aids another, such as an auxiliary remedy.
3. a nonspecific stimulator of the immune response.

aluminum adjuvant  an aluminum-containing compound, such as aluminum hydroxide or alum, that by combining with soluble antigen forms a precipitate; slow release of the antigen from the precipitate on injection causes prolonged, strong antibody response.
Freund's adjuvant  a water-in-oil emulsion incorporating antigen, in the aqueous phase, into lightweight paraffin oil with the aid of an emulsifying agent. On injection, this mixture (Freund's incomplete a.) induces strong persistent antibody formation. The addition of killed, dried mycobacteria, e.g., Mycobacterium butyricum, to the oil phase (Freund's complete a.) elicits cell-mediated immunity (delayed hypersensitivity), as well as humoral antibody formation.

adjuvant

(ăj′ə-vənt)
n.
1. A treatment that enhances an existing medical regimen, as a pharmacological agent added to a drug to increase or aid its effect.
2. An immunological agent that increases the antigenic response.
adj.
Contributing to or enhancing an existing medical regimen: adjuvant chemotherapy

adjuvant

[ad′jəvənt]
Etymology: L, ad + juvare, to help
1 a substance, especially a drug, added to a prescription to assist in the action of the main ingredient.
2 (in immunology) a substance added to an antigen that enhances or modifies the antibody response to the antigen.
3 an additional treatment or therapy.

Adjuvant

Referring to a management strategy used in addition to the primary therapy.
Immunology A substance that enhances or diversifies the immune response; a nonspecific immune enhancer—e.g., Freund’s adjuvant, BCG vaccine—consisting of particulate-rich oily substances which promotes protein aggregation; adjuvant mixed with an antigen acts as a tissue depot, slowly releasing antigen and activating the immune system.
Pharmacology A drug that modulates the actions of other drugs which, when added to a medication, enhances its pharmacologic effect. See Interference.

adjuvant

Immunology Any nonspecific immune enhancer–eg Freund's adjuvant, BCG vaccine, consisting of a particulate-rich oily substances, which promotes protein aggregation; adjuvant mixed with an antigen acts as a tissue depot, slowly releasing antigen and activating the immune system Oncology The addition of chemotherapy to a traditional therapeutic modality to ↓ M&M Pharmacology A substance which, when added to a medication, enhances its pharmacologic effect. See Neoadjutant.

ad·ju·vant

(ad'jū-vănt)
1. A substance added to a drug product formulation that affects the action of the active ingredient in a predictable way.
2. immunology A vehicle used to enhance antigenicity.
3. Additional therapy given to enhance or extend primary therapy's effect, such as in chemotherapy in addition to a surgical regimen.
4. A treatment added to a curative treatment to prevent recurrence of clinical cancer from microscopic residual disease.
[L. ad-juvo, pres. p. -juvans, to give aid to]

adjuvant

1. Any substance added to a drug to increase its effect.
2. Any substance which, added to an ANTIGEN, non-specifically increases its power to stimulate the production of antibodies (see ANTIBODY).

adjuvant

a substance added to enhance a physical or chemical property, e.g. adjuvants are commonly added to ANTIGENS, improving the IMMUNE RESPONSE in the recipient and thus increasing the production of ANTIBODIES.

adjuvant,

n a substance that improves the effectiveness of a medicine or enhances the ability to produce an immune response.

ad·ju·vant

(ad'jū-vănt)
1. Substance added to a drug product formulation that affects action of the active ingredient in a predictable way.
2. Additional therapy given to enhance or extend primary therapy's effect, as in chemotherapy's addition to a surgical regimen.
[L. ad-juvo, pres. p. -juvans, to give aid to]

adjuvant (aj´əvənt),

n an auxiliary active ingredient that supports the action of the basic drug. See also basis.

adjuvant

1. assisting or aiding.
2. a substance that aids another, such as an auxiliary remedy. Commonly used in reference to substances, commonly mineral oil or alum, added to vaccines to enhance antigenicity. See also freund's complete adjuvant.
References in periodicals archive ?
On December 2, 2014, the Company announced an update on the timeline for filing its New Drug Application (NDA) for the approval of PB272 (neratinib) in the extended adjuvant treatment of HER2-positive early stage breast cancer.
However, it must be pointed out that when Western and Asian studies were analysed separately, no survival benefit was found for receiving adjuvant treatment in patients in the Western groups [17].
Comprehensive side-effect profile of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: long-term safety analysis of the ATAC trial.
The aromatase inhibitor letrozole compares favorably with tamoxifen as an adjuvant treatment for hormone receptor-positive breast cancer in postmenopausal women, reported Dr.
tablets) for a new indication, adjuvant treatment of estrogen receptor
Berlex Bonefos review: FDA's Oncologic Drugs Advisory Committee will discuss Berlex' NDA (21-776) for Bonefos (clodronate) as an adjuvant treatment for the reduction of occurrence of bone metastases in Stage II/III breast cancer patients on Dec.
There is currently no consensus on the optimum management for early stage MCC, particularly regarding the role of postsurgical adjuvant treatment.
4-10) Overall, chemotherapy alone is generally considered to have little effect on survival, (11-14) but its efficacy as an adjuvant treatment has yet to be clarified.
These include the lead product candidate, pemtumomab, which was licensed from the Imperial Cancer Research Fund and is currently in a Phase III study as adjuvant treatment for ovarian cancer, with designated Orphan Drug status in the United States and European Union.
You suddenly start getting quite a substantial benefit of adjuvant treatment," Gray says.
Genentech disclosed today that it is now considering conducting trials to evaluate T-DM1 as an adjuvant treatment for HER2-positive breast cancer.
Growth of the French market is expected to be driven by increasing disease incident cases as the population ages, label extension of Stivarga as an adjuvant treatment for resected liver metastases patients, and the launch of expensive new therapies such as MGN-1703, a maintenance therapy for first-line patients responding to chemotherapy with or without biological agents.