Adjudin


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Adjudin

A non-toxic analogue of lonidamine which, in rats, causes reversible infertility, disrupting the junctions between nurse (Sertoli) cells in the testes, prematurely releasing sperm that don’t become functional gametes.
References in periodicals archive ?
Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans," Human Reproduction 28(1): 47-59.
Testin and actin are key molecular targets of adjudin, an anti-spermatogenic agent, in the testis," Spermatogenesis 1(2): 137-146.
An in vivo study on adjudin and blood-testis barrier dynamics," Endocrinology 150(10): 4724-4733.
Cheng was first put on the trail of Adjudin more than 15 years ago through the work of Professor Bruno Silvestrini, a colleague at the University of Rome, who was studying an anticancer drug, lonidamine.
Adjudin interferes with the adhesion of germ cells to the supportive Sertoli cells that surround them.
When Adjudin was administered orally at a high dose, however, it caused liver inflammation and muscle atrophy in a small subset of animals.
The Serteli-spermatid junctional complex adhesion strength is affected in vitro by Adjudin," Journal of Andrology 27(6): 790-794.