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A cytokine (for example, tumor necrosis factor-α, interleukin-6) produced by adipose tissue and acting locally in an autocrine-paracrine fashion or systemically as a hormone.
[adipo + G. kinēsis, movement]


A generic term for cytokines and other modulating proteins which are secreted by adipocytes. Some—e.g., IL-6—are pro-inflammatory,  whilst others—e.g., adiponectin—have anti-inflammatory or insulin-sensitising properties. Adipokine dysregulation appears to play a central role in adiposity, metabolic syndrome, and the co-morbidities of obesity including cardiovascular disease.


, adipokine (ad″ĭ-pō-sīt′ŏ-kīn″) (ad′ĭ-pŏ-kīn″) [ adipo- + cytokine]
A molecule secreted by fat cells that affects the physiology of cells in other parts of the body. Some of these molecules influence appetite, the storage of fat in the body, and systemic inflammation.
References in periodicals archive ?
All values of body composition, adipokine and T2DM risk factors are expressed as mean[+ or -]SE.
Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens.
2013) found that PCB-153 aggravates nonalcoholic fatty liver disease via adipokine dysregulation and altered lipid metabolism in HFD-fed mice but not in those fed a control diet.
He was able to achieve many new findings including reports on new adipokine, chemerin and new role of adipogenin and ghrelin receptor.
Apelin, a novel adipokine overproduced in obesity: friend or foe?
Adiponectin is one adipokine that is produced and secreted exclusively by adipocytes (7).
Also, weight loss was associated with changes in adipokine levels: Mean serum leptin concentration was decreased by 48% and serum level of adiponectin was increased by 21%, the authors reported.
Effects of PD regimen low in glucose on insulin resistance, body composition, adipokine profile and sympathetic overactivity in peritoneal dialysis patients.
As an adipokine, circulating Lcn2 level has been reported to be increase in obese humans [14], and laboratory animals [16], than lean controls.