Spectrophotometer Nanodrop readings to the concentrations of specific adhesion protein
By adding the Listeria adhesion protein
to the probiotic Lactobacillus paracasei, they were able to decrease the number of Listeria cells that passed through intestinal cells by 46 percent, a significant decrease in the amount of the bacteria that could infect a susceptible person.
Biotie is actively developing its pipeline assets, including SYN120, a unique potent 5-HT6/5-HT2a dual antagonist for which Biotie initially expects to conduct a Phase 2 study in Parkinson's disease dementia that is largely funded by the Michael J Fox Foundation; nepicastat, a selective inhibitor of dopamine beta hydroxylase which is currently in a Phase 2 study, fully funded by NIDA, for treatment seeking cocaine addicts; and BTT-1023, a monoclonal antibody targeting Vascular Adhesion Protein
1 for which Biotie intends to conduct a Phase 2 study in primary sclerosing cholangitis, a rare fibrotic disease of the liver.
The patent covers the use of the Company's proprietary cancer therapeutic agents to improve drug delivery to tumors by preventing a cell adhesion protein
, known as occludin, from forming cellular barriers within tumors.
Exherin(TM) is a novel tumor vascular targeting agent and is a small peptide molecule that specifically disrupts the blood vessels of cancers through inhibition of the cell adhesion protein
, N-cadherin, that is a critical structural component of some tumor blood vessels.
Exherin(TM) is a small peptide molecule that specifically disrupts the blood vessels of cancers through inhibition of the adhesion protein
It is the conformation of this sequence that enhances an adhesion protein
(or peptide that contains it) its receptor specificity and affinity.
This cell adhesion protein
is expressed by blood vessel cells but is different from the target of Exherin, Adherex's lead vascular targeting agent.
1 /PRNewswire/ -- Isis Pharmaceuticals (Nasdaq: ISIP) announced the initiation of Phase II clinical trials of ISIS 2302, an antisense inhibitor of intercellular adhesion molecule-1 (ICAM-1), a cell adhesion protein
involved in a wide range of inflammatory diseases.
In search of the underlying cause of this matrix disorganization, this proposal aims to determine how mechanoresponsive matrix adhesion proteins
react to mechanical perturbations and impact matrix remodeling in healthy and diseased tissue.
In addition, pH stabilizers such as dimethicone are important, as the skin acidity in skin of color is lower and needs to be maintained to prevent degradation of skin adhesion proteins
Known human proteins (n = 34), such as apo-lipoproteins, complement proteins, coagulation proteins, and adhesion proteins
, were identified in more than one independent sample of RA patients.